Research Associate in Chemical Biology

University College London - UCL Chemistry

Applications are invited for a Research Associate to work in the group of Dr Derek Macmillan, in the Department of Chemistry at the Bloomsbury Campus of University College London. This EPSRC-funded position is available working in the field of chemical biology. The project aims to utilize genetic tools to enable introduction of modified amino acids into proteins. The project will further aim to use these introduced amino acids to facilitate selective protein conjugation reactions and template the formation of complex biomolecules.

The postholder will be required to design and execute efficient synthetic pathways to modified peptides as model systems as well as create libraries of mutant tRNA synthetase enzymes. The project will make extensive use of selection and screening approaches to identify tRNA synthetase clones capable of aminoacylating tRNA and incorporating our modified amino acids into target proteins.

The post is funded by the EPSRC for 24 months initially, and is available as soon as possible. The successful applicant will join a highly motivated group working at the interface of organic and biological chemistry.

The successful candidate must possess a strong background in organic chemistry and also elements of molecular and cell biology (ideally PCR and genetic library creation, molecular cloning and protein expression from E. coli ) although some training can be given. The successful candidate will have a PhD. in Organic Chemistry/ Chemical Biology or about to be awarded a PhD .  

Please note, appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment w ill be at Research Assistant Grade 6 (salary £30,316 - £31,967 p.a. including London Allowance of £3,031 p.a.) with payment at Grade 7 being backdated to the date of final submission of the PhD the sis.

The appointment will be on UCL Grade 7. The salary range will be £34,635 to £41,864 per annum, inclusive of London Allowance.

UCL vacancy reference: 1706729       

Applicants should apply online. To access further details about the position and how to apply please click on the ‘Apply’ button below.

Informal enquiries should be addressed to Dr. Derek Macmillan ( Any queries on the online application proces can be directed to Judith James (, as we wish to encourage online applications.

Interview Date: TBC

We particularly welcome applications from black and minority ethnic candidates as they are under-represented within UCL at this level.

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