Research Fellow in Modelling and Inference of Self Organisation in Cell Division (88190-028)

University of Warwick - Department of Mathematics

Fixed term contract for 4 years.

Applications are invited for a postdoctoral research fellow to work with Professor Burroughs and his collaborators on the modelling and statistical inference of chromosome movements during cell division. By inferring the mechanics of chromosome movements, the aim is to develop a (data driven) mechanistic 3D dynamic model of the self-organising processes that lead to accurate separation of chromosomes to two daughter cells and how this goes wrong. It thus has relevance to cancer and development disorders. The project will develop and implement Bayesian algorithms to fit (infer) mechanics inspired models to 3D chromosome trajectories generated from tracking in imaging time-series. The models are hidden Markov models with an unknown number of states coupled to a Brownian motion (stochastic differential equation) dynamic model. The project is a collaboration between Burroughs’ theory group and an experimental lab in Warwick Medical School.

The ideal candidate will have a relevant PhD, e.g. in statistics/mathematics/physics, and have a strong background in stochastic modelling and/or computational statistics. A background in HMM inference using Markov chain Monte Carlo (MCMC) algorithms will be beneficial, whilst an ability to programme in MatLab, C++ a distinct advantage. A willingness and enthusiasm for communicating with biologists is encouraged. A background in biology is NOT required.

The post is for 48 months, start date ideally before June 2018 but flexible.

Applications via the HR website should include 1) a letter of application outlining previous research and why you are interested in the post, 2) a CV, 3) a list of publications, and 4) links to a small selection of reprints/preprints/publications from your PhD/latest research post as appropriate. Scientific queries about the project can be made to Prof Burroughs, N.J.Burroughs@warwick.ac.uk, or see his website https://warwick.ac.uk/fac/cross_fac/zeeman_institute/staffv2/burroughs/.

Interviews will take place in late March/early April.

Full details of the duties and selection criteria for this role are found in the vacancy advert on the University of Warwick jobs page. You will be routed to this when you click on the Apply button below.

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Midlands of England