Research Fellow (Computational Chemistry)

Cardiff University

To lead or work within research projects, undertaking computational modelling and analysis of proteins and small molecules to aid identification of pre-candidate molecules. The role holder will contribute to the design and optimization of small molecule inhibitors within a project team of medicinal/synthetic chemists, biochemists, and biologists using state of the art modelling and chemo-informatics approaches. In addition to design and implementation of virtual 2D and 3D screening, the role holder will advance the lead optimisation by the application of expert data analysis (predicted, biological, physiochemical etc.) to the design of prospective target molecules and generation of new intellectual property. 

The newly-established Medicines Discovery Institute represents a major investment in translational science by Cardiff University. The goal of the Institute is to translate world-leading research on scientific understanding of disease mechanisms into innovative therapeutic approaches.  Our vision is to play a leading role in discovering new medicines in areas of high unmet need, with a particular emphasis on, but not exclusive to, neuroscience and mental health. We are creating a vibrant community of researchers across both academic and biotech sectors engaged in major research programmes which build off the unique strengths of Cardiff University and work collaboratively with other universities and companies across Wales and internationally.  Building off investment from both the European Regional Development Fund through the Welsh Government’s Sêr Cymru scheme and Cardiff University, we will recruit a number of key academic, research and operational roles to work alongside the current and future grant & industry funded staff.

In addition to a number of live drug discovery projects running at Cardiff University, funded principally by the Wellcome Trust and the MRC, we are establishing a new drug discovery group to establish a pipeline of projects.  This team will work closely with scientists across Cardiff University and beyond, to start to translate exciting new discoveries in neuroscience and mental health into potential new medicines for onward development through both academic and commercial routes.

This position will be based at Cardiff University and will be part of a multi-disciplinary drug discovery team.  We are looking for an individual with a strong passion for enabling and leading drug discovery projects through computational chemistry expertise, with extensive experience of medicinal chemistry and drug design in an academic or commercial environment.

This post is full-time and fixed-term for 5 years from 1 August 2018.

Please be aware that Cardiff University reserves the right to close this vacancy early should sufficient applications be received.

Cardiff University is committed to supporting and promoting equality and diversity and to creating an inclusive working environment. We believe this can be achieved through attracting, developing, and retaining a diverse range of staff from many different backgrounds who have the ambition to create a University which seeks to fulfil our social, cultural and economic obligation to Cardiff, Wales, and the world. In supporting our employees to achieve a balance between their work and their personal lives, we will also consider proposals for flexible working or job share arrangements.

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