PhD Studentship - Developing an Anti-androgen with a Unique Mode of Action for the Treatment of Castration Resistant Prostate Cancer

University of Surrey

Start of Studentship: 01 October, 2018

The doctoral college of the University of Surrey is offering some competitive PhD studentships to start from January 2018. They are 3-year, fully-funded and cover the tuition fee for EU/UK students, and offer a tax-free yearly stipend of approx. £14,777.

Apply link:

One of the projects is available in Dr Mohammad Asim’s lab who leads the section of Oncology in the Department of Clinical and Experimental Medicine (See lab website.docx). The outline of the project is as below:

Project Discription

Prostate cancer (PrCa) is a leading cause of cancer related male mortality in the United Kingdom with over 10,000 deaths each year. The growth and progression of PrCa is regulated by androgens, which manifest their action by activating the androgen receptor (AR), a ligand activated transcription factor that in turn regulates the growth of PrCa. Since AR signaling is upregulated in PrCa, it is an attractive drug target in the treatment of the advanced PrCa. Hence, widely used androgen deprivation therapy (ADT) is the mainstay treatment for PrCa, which is achieved by the use of anti-androgenic drugs such as Bicalutamide and Enzalutamide. ADT is initially effective but relapse is common leading to castration resistant prostate cancer (CRPC) for which there are no curative treatments. The key question is why does ADT fail and how can we develop more effective anti-androgens to target the AR? In collaboration with the Department of Chemistry University of Cambridge and Nuffield Department of Surgery University of Oxford, this project will discover novel anti-androgens to develop curative treatment for CRPC. The findings of this study will pave the way to effectively treat CRPC in order to alleviate the disease burden.

Lab website: 

Funding Notes

Eligible students can apply for funded projects on a competition basis for a doctoral college studentship award (View Studentship Website). Self-funded students can also apply and suitably qualified international candidates may be eligible for a fees reduction.

Eligibility: You must have, or expect to achieve, at least a 2:1 honours degree or international equivalent. Students with a lower first degree and a MSc will also be considered. If English is not your first language, you must have IELTS 7 with at least 6.5 in all the components. 

How to apply: Please email for more details and advice of completing the studentship form before applying through the University’s Doctoral College to discuss the project

Don’t be deterred from applying because of Brexit. As of 21 April 2017, the Department for Education released a statement announcing:

“EU students applying for an undergraduate or master’s course at an English university or further education institution in the 2018 to 2019 academic year will continue to have access to student loans and grants, even if the course concludes after the UKs exit from the EU.”

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