Research Fellow in Protein Biochemistry

University of Leeds - School of Chemistry

Are you an experienced protein biochemist looking for your next challenge? Are you interested in applying your research skills to address important protein-sugar interactions underpinning virus and bacterial infections? Do you want to further your career in one of the UK's leading research intensive universities?

We are looking for a Research Fellow to join our multidisciplinary team and work on a BBSRC funded project to develop glycan-functionalised quantum dots (QDs) as novel multifunctional probes to dissect multivalent protein (DC-SIGN & DC-SIGN/R)-glycan interactions.

Working closely with the Research Fellow in Carbohydrate Nanochemistry, you will clone, express, and purify a series of mutant DC-SIGN/R and label them site-specifically with fluorescent dyes and quantify their binding affinity, kinetics and thermodynamics with glycan-QDs via fluorescence techniques to elucidate the structural basis of their different CRD presentation. Using fluorescent glycan-QDs as virus mimetics, you will study how glycan valency and binding affinity affect their interaction with DC-SIGN/R-expressing cells and intracellular pathways using confocal fluorescence microscopy and electron microscopy.

You will have a PhD in Protein Biochemistry and/or Cell Biology, the ability to carry out protein biochemistry experiments independently and excellent practical skills in protein characterisation and cellular imaging techniques. You will also have a good knowledge of nanochemistry.

To explore the post further or for any queries you may have, please contact:

Dr Dejian Zhou, Senior Lecturer, Tel: +44 (0)113 343 6230, Email:

Location: Leeds - Main Campus
Faculty/Service: Faculty of Mathematics & Physical Sciences
School/Institute: School of Chemistry
Category: Research
Salary: £32,548 to £38,833 p.a. Due to external funding restrictions, an appointment will not be made above £32,548 p.a.
Working Time: 37.5 hour per week
Contract Type: Fixed Term (36 months)

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Northern England