Research Associate or Senior Research Associate - Computational Medicinal Chemistry

UCL Institute of Neurology - Alzheimer’s Research UK - Drug Discovery Institute

The newly formed Alzheimer’s Research UK Drug Discovery Institute (ARUK UCL DDI), located at University College London (UCL), is part of a network of world class Drug Discovery Institutes, with the goal of finding new treatments for neurodegenerative disease.  As part of the Institute of Neurology, it will be integrated into the world-renowned UCL Neuroscience community. Lead academic scientists supporting the activities of the ARUK UCL DDI are Institute of Neurology Professors Giampietro Schiavo, John Hardy and Bart de Strooper. The DDI will work closely with the UCL Department of Chemistry and drug discovery groups already established within the UCL campus.  

A computational medicinal chemist is sought to join this exciting and novel initiative. Working with the Head of Chemistry, the post-holder will contribute to the evaluation of project opportunities and definition of medicinal chemistry plans for selected projects. The post-holder will work collaboratively with medicinal chemistry and biology colleagues, to develop and utilise computational medicinal chemistry and chemoinformatic tools for target identification and validation to underwrite new mechanisms for the treatment of neurodegenerative disease and dementia.

Applicants must a PhD in organic chemistry or computational organic chemistry, or equivalent experience, with expert knowledge of theoretical and practical computation medicinal chemistry and chemoinformatics as applied to hit and lead optimisation.  The ability to collaborate with medicinal chemistry colleagues on the design of novel compounds to rationally improve the potency and DMPK properties of the hits and leads is essential, as is the ability to apply structure based and ligand based design to identify ligands for novel dementia targets.

Candidates applying for Grade 8 must additionally have experience of design and triage specific small molecule screening libraries using commercial and custom compounds, knowledge of contemporary medicinal chemistry and drug design and experience of applying computational medicinal chemistry knowledge to the successful delivery of drug discovery projects in academic, industry ort biotech. The ability to design, setup and evolve computation and chemoinformatic infrastructure is also a requirement as is experience leading a team of researchers.

The post is funded by a grant from ARUK for the period to August 2020 in the first instance and is available immediately, but the start date is flexible. Salary on UCL Grade 7 for the Research Associate in the range of £34,635 - £41,864  per annum including London Allowance, or on UCL Grade 8 for the Senior Research Associate in the range of £43,023 - £50,753 per annum including London Allowance.

You should apply for this post through UCL's online recruitment – where you can download a job description and person specification using ref: 1713431.

If you have any queries regarding the application process, please contact Oksana Shapoval, HR Officer, Institute of Neurology, 23 Queen Square, London, WC1N 3BG (email: For further information on the post, please contact Professor Paul Fish (email:

Closing date for applications: 26 March 2018

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