Research Fellow

The University of Edinburgh - Edinburgh Cancer Research Centre - the Institute of Genetics and Molecular Medicine

Applications are invited for a Cancer Research UK funded Postdoctoral Research Fellow position in the laboratories of Dr Kevin Myant and Dr Farhat Din at the Edinburgh Cancer Research Centre within the Institute of Genetics and Molecular Medicine, Western General Hospital. The Myant and Din labs investigate the mechanisms important for colonic stem cell transformation and colorectal tumour progression with a particular focus on how changes in RNA splicing mediate these processes. We are particularly interested in identifying and validating tumour cell specific vulnerabilities that may be utilised for the development of new therapies to treat this disease. The labs have recently been awarded funding from Cancer Research UK to determine whether inhibition of a specific component of the RNA splicing machinery can impair tumour cell growth. Using a combination of 3D organoid models derived from mouse and human colons, advanced animal models, omics approaches and histopathology the project aims to carry out a comprehensive validation of this RNA splicing target. This work will feed into an established drug development programme and other mechanistic work being carried out in the labs with the ultimate aim of developing first in class inhibitors for the treatment of colorectal cancer.

The contract is for 2 years with possibility of applying for additional funding to extend it at the 18 month stage. Applicants must have, or will shortly obtain, a PhD in a relevant subject area and should have experience with mammalian tissue culture, RNA expression analysis and gene expression technologies. Experience with murine disease models, 3D organoid culture and gene targeting technologies (eg. CRISPR) would be highly advantageous. The successful candidate will be highly motivated, enthusiastic, show good communication skills and the ability to work as part of a team.

This is a fixed term 2 year contract.

For more information and to submit an application, please use the ‘apply’ button below.

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