MRC Postdoctoral Research Scientist

MRC London Institute of Medical Sciences

Fixed-term, 3 years

Novel models to study senescence and the SASP in cancer and aging

Our lab has a long-standing interest in studying senescence. For example, we have contributed to understand the role of senescence as a tumour suppressor mechanism (Collado et al. Nature 2005), in limiting iPSC reprogramming (Banito et al. Genes Dev 2009; Aarts et al. Genes Dev, 2017) or activating immune surveillance (Kang et al. Nature 2011). We have also contributed to identify molecular mechanisms controlling the senescent growth arrest (Gil et al. Nat Cell Biol 2004; Tordella et al. Genes Dev 2016) or the inflammatory phenotype associated with senescence (Acosta et al. Cell 2008; Acosta et al. Nat Cell Biol 2013; Herranz et al. Nat Cell Biol 2015).

You will work on the identification and characterization of mechanisms regulating senescence and the senescence-associated secretory phenotype (SASP) in cancer and age-related diseases. The project will benefit of novel mouse models developed in our lab and yet unpublished insights on SASP regulation obtained from large scale screens carried out by us.

Experience with animal work is required. Experience in senescence, cancer research or genetic and drug screens would be useful, but is not essential. A strong background in molecular and cellular biology is required. Experience working with primary cells, familiarity with retroviral and lentiviral systems, with genetic or drug screens or with high content microscopy systems (such as InCell 2000) would be highly valued. All applicants should have a Ph.D. degree in life sciences or equivalent experience and at least one first-author publication published or in press. A Home Office Personal License is desirable but not essential. In return, we offer a highly attractive benefits package including 30 days annual leave plus bank holidays and privilege days, competitive salary, a defined benefit pension scheme and access to employee shopping/travel discounts and salary sacrifice cycle to work scheme.

The LMS is directly funded by the Medical Research Council, and associated with Imperial College. The LMS provide excellent core facilities and support structures, including automated microscopy systems, next generation sequence and proteomics. The Cell Proliferation Group is part of the Epigenetics Section and interacts with other groups in the LMS studying cell cycle, cancer, and chromatin organisation.

For informal enquiries, please contact Jesús Gil via email (jesus.gil@lms.mrc.ac.uk)
Cell Proliferation Group web page: https://lms.mrc.ac.uk/research-group/cell-proliferation/

For full details of this post and to complete an online application, visit https://mrc.tal.net/vx/lang-en-GB/appcentre-1/candidate/postings/895 and upload your CV, names and contacts of two scientific references along with a covering letter stating why you are applying for this role (providing evidence against the requirements of the job as per the job description and person specification). Please quote reference number LMS 804.

*Salary quoted is inclusive of London weighting. A £1,000 lump sum Settlement Allowance will be paid on taking up the post.

The MRC London Institute of Medical Sciences is a research institute within UK Research and Innovation. UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at www.ukri.org

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