Postdoctoral Research Scientist in Cardiovascular Regenerative Medicine

University of Oxford - Department of Physiology, Anatomy and Genetics

Grade 7

Applications are invited for the post of Postdoctoral Research Scientist to be part of a cohesive team working under the supervision of Professor Paul Riley and Professor Angela Russell on a project focused on the development of small molecule stimulators of epicardial EMT to augment the process of EPDC activation and differentiation towards either a cardiac muscle or coronary vascular smooth muscle cell fate, in vivo, in mouse. A collaboration between the Riley and Russell laboratories, formed as part of the recently renewed British Heart Foundation Oxbridge Centre of Regenerative Medicine. The funds supporting this research project are provided by the BHF Oxbridge Centre for Regenerative Medicine (CRM).

In 2013 The University of Oxford was awarded £2.5 million over 4 years to establish a British Heart Foundation Centre of Regenerative Medicine (BHF CRM). The Centre, in partnership with the Universities of Cambridge, Bristol and Manchester, was renewed in 2017 and awarded a further £2.5 million over 4 years. The Regenerative Medicine Centre contains 13 Principal Investigators and 15 Core Collaborators (from Oxford, Cambridge, Bristol and Manchester) under the Directorship of Professor Paul Riley (BHF Professor of Regenerative Medicine).

We are seeking someone carry out studies including RNAseq studies using an optimal dose of our most promising hits compared to vehicle control in human epicardial cells and global proteomic and phosphoproteomic analysis. To use a parallel approach utilising chemical proteomics to determine the molecular target(s) of our most promising hits and demonstrate target validation and engagement. The postdoctoral research scientist will characterise pro-regenerative signals from human epicardium and identify pro-regenerative small molecules.

The successful applicant will contribute intellectually to the development and management of the project. Will hold, or be near completion of, a PhD/DPhil and will test hypotheses, analyse data and review/refine working ideas as appropriate. Assist members of the group or people working on collaborative projects. Contribute ideas for new research projects and develop ideas for generating research income. Prepare scientific reports, represent the research group at external forums (eg scientific conferences) through oral and poster presentations. Write up results for publication in international peer-reviewed journals and demonstrate initiative and contribute to tasks helpful to the smooth running of the research project.

You will be based across two sites: the Sherrington Building, South Parks Road, Oxford, OX1 3PT and The Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS.

This post is fixed-term for 3 years from start date (funding end date: 30 September 2021)

For further information please contact Professor Paul Riley (paul.riley@dpag.ox.ac.uk) of Professor Angela Russell (angela.russell@chem.ox.ac.uk).

The closing date for applications is 12.00 noon on Wednesday 9 May 2018. Interviews are expected to be held week commencing 21 May 2018.

https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.jobspec?p_id=134048

Closing Date: 09-MAY-2018 12:00

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