Postdoctoral Research Scientist in Cardiovascular Regenerative Medicine

University of Oxford - Department of Physiology, Anatomy and Genetics

Grade 7

Applications are invited for the post of Postdoctoral Research Scientist in Dr Nicola Smart’s research group on a project focusing on enhancing myocardial and coronary vascular regeneration, based upon understanding and enhancing endogenous responses and by stimulating reactivation of developmental mechanisms. Nicola’s recent research has demonstrated contributions from two specific developmental sources after myocardial infarction (MI): the ventricular endocardium and the coronary sinus (the adult derivative of the sinus venosus). We found that the quiescent epicardium is reactivated and, while direct cellular contribution to new vessels is minimal, it supports the directional expansion of the neovessel network towards the infarcted myocardium.

The successful applicant will be responsible for the management of the project by coordinating multiple strands of work to meet deadlines. They will be required to perform myocardial infarction surgery and analyse endogenous neovascular responses over a time course. They will analyse expression of well-characterised enhancer reporter lines post-MI and isolate endocardial and coronary endothelial cells and perform RNAseq The post-holder will contribute ideas for new research projects and for generating research income. They will also be required to act as a source of information and advice to other members of the group on scientific protocols and experimental techniques.

We are seeking someone with expertise in basic molecular biology techniques, ideally including platforms such as Next Generation Sequencing (eg. RNAseq studies); microscopy/imaging and genetic manipulation. They should have in vitro experience in cell culture and experience or interest in growing and maintaining human induced pluripotent stem cells and human primary cells from biopsies. The successful applicant will also hold, or be near completion of, a PhD/DPhil in cardiovascular sciences. The postholder should have a personal license to work with rodents in the UK or be prepared to obtain such a license via attendance of in-house courses.

The closing date for applications is 12.00 noon on Wednesday 9 May 2018. Interviews are expected to be held on Friday 18 May 2018.

Closing Date: 09-MAY-2018 12:00

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South East England