Laboratory Research Scientist

The Francis Crick Institute

Contract: Fixed term (3 years), full time

Short Summary

We are looking for a highly motivated Laboratory Research Scientist to join the Sex Chromosome Lab at the Francis Crick Institute. We use diverse organisms and in vitro models to understand male-female differences in development, disease and stem cell biology. The successful candidate will work on a new translational stem cell project working closely with a postdoctoral scientist in the lab as well as our industry collaborators at AstraZeneca. Candidates should have a strong background in molecular biology techniques and excellent organisation skills. Experience in stem cell culture would be highly desirable.

Project Scope

The Laboratory Research Scientist will work on a recently awarded AstraZeneca-Crick project. We aim to use human pluripotent stem cell models to study human sex differences in stem cell derived cardiomyocytes. Cardiovascular diseases show significant sex biases in their epidemiology. Women are more prone to developing electrophysiological disturbances of heart rhythm whereas men are more predisposed to structural damage to the heart muscle. We want to explore to what extent these differences are genetically encoded. Furthermore, our research will have practical and direct translational potential. Cardiotoxicity is the leading cause of failure in pre-clinical drug development. Using our model, we can interrogate if inclusion of sex as a biological variable improves the sensitivity and specificity of cardiovascular toxicology studies.

About Us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

The closing date for applications is 11 May 2018 at 23:30.

All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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