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Postdoctoral Research Fellow/Associate in NMR Structural Studies of Protein-Drug Interactions

University of Leicester - Leicester Institute of Structural and Chemical Biology/Molecular and Cell Biology

Location: Leicester
Salary: £33,518 to £47,722 Grade 7 or 8 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 30th August 2018
Expires: 31st October 2018
Job Ref: 188
 

About the role

A one year postdoctoral position is available for a talented protein NMR spectroscopist with a strong interest in protein structural studies and their application to drug discovery. The postdoctoral scientist will work in Prof. Mark Carr’s group on a successful collaborative research programme fully funded by the pharmaceutical company UCB Biopharma. The project will involve the determination of solution structures for proteins targeted by UCB Biopharma drug discovery programmes and detailed characterisation of their interactions with candidate drugs, which may be small molecules or therapeutic antibodies. The proposed work will involve close interactions with experienced research scientists at UCB Biopharma and will be supported by their extensive protein expression, purification and biophysical facilities. The Leicester Institute of Structural and Chemical Biology is superbly equipped for all aspects of NMR-based structural biology, including 500, 600 (x2) and 800 MHz NMR spectrometers with cryoprobes, and excellent computer facilities.

LISCB comprises over 20 research groups drawn from several departments, including the Department of Molecular and Cell Biology, and brings together internationally renowned research using structural biology, chemical biology and single molecule methods to investigate major challenges in fundamental biological processes into a single world-leading unit.

About you

You will have proven experience in many aspects of NMR-based structural biology of proteins and protein-ligand complexes, and have a strong interest in knowledge-based drug discovery. Previous experience in protein expression and purification is desirable but not essential. The ability and willingness to travel to meetings with collaborators and to use off-campus research facilities is essential. Good communication and presentation skills are also a pre-requisite.

Additional information

This post is available at Grade 7 (Postdoctoral Research Associate) or Grade 8 (Research Fellow) depending on experience. 

Informal enquiries are welcome and should made to Prof. Mark Carr, Tel: +44 (0)116 229 7075, Email: mdc12@le.ac.uk, or Dr Lorna Waters, Tel: +44 (0)116 229 7051, Email: lw83@le.ac.uk 

This advert will remain open until the position is filled. Applications are reviewed every Wednesday.

   
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