|Funding for:||UK Students, EU Students|
|Funding amount:||Not Specified|
|Placed On:||13th September 2018|
|Closes:||5th December 2018|
We are seeking a highly motivated student with a strong academic background in natural sciences and an interest in biophysical methods to work with Prof. Sophie Jackson on the physical stability of therapeutic peptides. The PhD position is a BBSRC DTP Industrial CASE award in collaboration with and partially funded by MedImmune (the biopharmaceutical subsidiary of AstraZeneca). The student will get to spend some time working within the company during their PhD.
The projects will focus on a study of the chemical and organic impurities arising during MEDI0382 Drug Substance (DS) and Drug Product (DP) manufacture under different process conditions, exploring the relationship between these impurities and the physical stability of the peptide. The aim will be to gain a better understanding of the mechanisms underlying gel and fibril formation and how this relates to the different processing conditions. We will aim to identify predictors of early fibril formation and physical instability in the formulated Drug Product, and to identify predictors of early fibril formation leading to physical instability in synthetic peptide formulations. The project will be interdisciplinary with emphasis on physical methods (such as mass spectrometry and solid-state NMR) to study peptide purity, structure and aggregation.
Applicants should have (or expect to obtain) the equivalent of a UK first class or upper second class honours degree (and preferably a Masters degree) in chemistry, biochemistry, physics, or other relevant discipline, and must have an interest in using physical methods to study biological systems. The studentship will provide a maintenance grant and tuition fees at the UK/EU rate, and is available to UK and EU students who meet the UK residency requirements of the Research Councils. Students from EU countries who do not meet the residency requirements may be eligible for a fees-only award. Owing to funding restrictions imposed by the sponsor, non-EU citizens cannot be considered.
Applications must be made online via the University Applicant Portal (see www.ch.cam.ac.uk/pgapp). Please note that there is an application fee. As part of your 'Statement of Research Interest' you must state that you are applying for the BBSRC Industrial CASE studentship with Prof. Jackson. All applicants will also be considered for other studentships available in the Department of Chemistry.
Information about research in the Department of Chemistry is given at: www.ch.cam.ac.uk
Please quote reference MA14644 on your application and in any correspondence about this vacancy.
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