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PhD Studentship: Small Non-Coding RNAs with a Big Impact on the Development of Skeletal Muscle (MUNSTERBERG_U19DTP)

University of East Anglia - School of Biological Sciences

Qualification Type: PhD
Location: Norwich
Funding for: UK Students, EU Students
Funding amount: £14,777 pa
Hours: Full Time
Placed On: 9th October 2018
Closes: 26th November 2018

Start date: 1/10/2019

Supervisor Andrea Munsterberg

Project description

Skeletal muscle is important for health and well-being throughout life. To understand better the factors that contribute to the maintenance of this important tissue, we study its development in the embryo. It is known that many of the genes and mechanisms that control embryo development are conserved and perform similar functions in the adult organism. This is also the case for small non-coding RNAs, called microRNAs, which are highly expressed in developing and mature skeletal muscles, where they can have protective function, for example in ageing or disease. To discover the full potential of microRNAs for healthy muscles we are using functional experiments in early avian embryos in ovo. We showed that muscle specific microRNAs negatively regulate the expression of crucial transcription factors and epigenetic regulators (Pax3, Gli3, BAF60a/b). This is essential to provide robustness to developmental timing during the progenitor to myoblast transition, and to stably establish the myogenic differentiation programme. This new project will investigate further the role of miR-133 in myogenesis, using established approaches novel targets will be validated and their role in early muscle development will be tested. The student will be fully integrated into a lively laboratory investigating different aspects of skeletal muscle and cardiac development in avian embryos.

Person Specification UK 2:1 & English Language (6.5 overall, 6 in each section)

Funding notes For funding eligibility guidance, please visit our website: http://biodtp.norwichresearchpark.ac.uk/how-to-apply/funding-and-eligibility. Full Studentships cover a stipend (UKRI rate: £14,777 pa – 2018/9), research costs and tuition fees at UK/EU rate and are available to UK and EU students who meet the UK residency requirements.  

Students from EU countries who do not meet the UK residency requirements may be eligible for a fees-only award. Students in receipt of a fees-only award will be eligible for a maintenance stipend awarded by the NRPDTP Bioscience Doctoral Scholarships. To be eligible students must meet the EU residency requirements.  

This project has been shortlisted for funding by the Norwich Biosciences Doctoral Training Partnership (NRPDTP). Shortlisted applicants will be interviewed as part of the studentship competition. Candidates will be interviewed on either the 8th, 9th or 10th January 2019. 

The NRP DTP offers postgraduates the opportunity to undertake a 4-year research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP students undertake a three-month professional internship (PIPS) during their study. The internship offers exciting and invaluable work experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team. Students with, or expecting to attain, at least an upper second-class honours degree, or equivalent, are invited to apply. 

For further information and to apply, please visit our website: www.biodtp.norwichresearchpark.ac.uk 

   
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