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Research Associate

Imperial College London - Department of Surgery and Cancer

Location: London
Salary: £37,904 to £45,747 per annum
Hours: Full Time
Contract Type: Permanent
Placed On: 19th October 2018
Closes: 20th November 2018
Job Ref: MED00835
 

Campus: South Kensington –Main campus however you will be required to work at Charing Cross, St Mary’s and Hammersmith

The post holder will join a European Research Council funded study aimed at the development of novel analytical approaches for the diagnostics of mucosa-associated diseases (MASSLIP).

The mass spectrometry lab at Imperial College is seeking an outstanding research assistant interested in taking on a challenging role with considerable scope for independent scientific achievement and personal growth. The post-holder will be a key member of the research staff supporting the study.  Professor Takats has been an international leader in applications of advanced ambient mass spectrometric methods to medicine.

The MASSLIP study includes a number of sub-projects each of them focusing either on certain aspects of mucosal sampling or the diagnostic of a group of diseases. The study employs mostly ambient ionization mass spectrometric (AIMS) methods for the diagnostic and prognostic of infectious diseases, cancer and various immunological diseases. The utilisation of lasers as both surgical instruments, and ionisation mechanisms in mass spectrometry, such as MALDI-ToF MS, is well established. Laser-REIMS is a novel developed concept that replaced the diathermic iknife in REIMS and is being successfully used for biological material ablation, tissue imaging analysis and lipidomic analysis. While the introduction of matrix into Laser-REIMS atmospheric interface enhances the signal intensity and also expands the range of detectable molecular species, it has a negative effect on the robustness of the technology. Novel matrix introduction setups based on the application of diverse metal nanoparticles coating and labelling technology will be constructed and tested using a cell line-based test set and cancer tissues in order to maximise the detectability of subtle differences in the spectral patterns and imaging resolution.

The post involves the organization and administration of ambient mass spectrometric mucosal sample analysis and instrumentation development. There is considerable scope for career growth within the post. 

The successful candidate will have a PhD in Chemistry or Biology, or a closely related discipline or equivalent research.  Experience in the synthesis and application of diverse nanomaterials, including gold, silver and iron oxide nanoparticles is essential, as is extensive experience in handling and preparing biofluid and biological tissue samples.

The contract is full time and fixed term until 31 May 2019.

For informal inquiries or questions about the role, please contact Professor Zoltan Takats directly at Zoltan.takats@imperial.ac.uk

Imperial Expectations guide the behaviour of all our staff.

For technical issues when applying online, please contact: recruitment@imperial.ac.uk.

Committed to equality and valuing diversity, we are also an Athena SWAN Silver Award winner, a Stonewall Diversity Champion, a Disability Confident Employer and are working in partnership with GIRES to promote respect for trans people.

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

   
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