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DPhil Studentship: The Role Of The Brain Neurovascular Unit In Dementia Pathogenic Mechanisms

University of Oxford

Qualification Type: PhD
Location: Oxford
Funding for: UK Students, EU Students, International Students
Funding amount: Not Specified
Hours: Full Time
Placed On: 17th December 2018
Closes: 1st March 2019

Supervisor:
Dr Zameel Cader https://www.ndcn.ox.ac.uk/research/translational-molecular-neuroscience-group 

Applications are invited from enthusiastic and highly driven candidates who wish to pursue studies for a fully funded DPhil (PhD) degree in the biology of neurovascular function in dementias at the University of Oxford. The research will focus on human induced pluripotent stem cell models of the blood-brain-barrier. The models will be developed from healthy subject iPSC lines or patients with dementia associated gene variants and then exposed to disease relevant perturbations. The disease mechanisms and effect on neurovascular interactions will be explored using molecular profiling and functional assays such as calcium imaging and multi-electrode array recordings. As such the project will offer training in a sophisticated set of methodologies and ample opportunities for collaboration: The Cader laboratory is part of the Nuffield Department of Clinical Neurosciences and based at the Weatherall Institute of Molecular Medicine and Dunn School of Pathology. The project will be carried out within a broader EU-wide network of collaborations including substantial interactions with leading pharmaceutical industries, specifically as part of the IM2PACT project.

Candidates are expected to have demonstrated an ability to work effectively in the laboratory, a strong background in molecular biology and experience in stem cell technologies and an excellent undergraduate degree in a relevant discipline (e.g. biochemistry, cell biology or neuroscience). An undergraduate 1st class or upper 2nd class degree (or equivalent grade) is required for graduate entry into Oxford. The minimum standards for English apply for applicants. Funding will cover living expenses and course fees up to the value of a Home/EU student.

Formal applications must be made via the University online application system. The relevant course code is: Doctor of Philosophy in Clinical Neurosciences RD_CU1. Please enter the reference code “19CLINNEUO02WEB” when applying for this studentship. In the cover letter, please describe the research skills you have already acquired and clarify how your experience and skills would help you in your doctoral studies.

Please direct any enquiries about this project to Dr Zameel Cader: zameel.cader@ndcn.ox.ac.uk

The closing date for applications is 12.00 noon on the 1st March 2019

   
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