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Fully Funded KESS II PhD Scholarship: Therapeutic Targeting of Vulnerabilities in mTORC1 Overactive Tumours

Swansea University - Medical and Health Care Studies (Cancer Therapeutics)

Qualification Type: PhD
Location: Swansea
Funding for: UK Students, EU Students
Funding amount: £14,483 per annum
Hours: Full Time
Placed On: 8th January 2019
Closes: 22nd February 2019

*This scholarship is part funded by the Welsh Government’s European Social Fund (ESF) programme for East Wales.*

Inappropriate activation of mammalian/mechanistic target of rapamycin complex 1 (mTORC1) is common in cancer and has many cellular consequences including impaired stress responses. These abnormal stress responses can be targeted to develop new therapeutic approaches to the treatment of cancer.

We have recently identified that genetically defined mTORC1 hyperactive tumour cells are sensitive to a combination of endoplasmic reticulum stress inducing drugs (Johnson et al, 2018). This studentship will build upon this and develop additional therapeutic strategies that target stress responses in mTORC1 hyperactive cells, in a variety of in vitro models. The work will encompass a broad range of cell culture and molecular biology techniques.

The successful applicant will be registered as a postgraduate research student at Swansea University Medical School (https://www.swansea.ac.uk/medicine/) under the primary supervision of Professor Conlan. However, the student will be based in the North Wales Clinical Research Centre (NWCRC). The NWCRC consists of a team of clinicians, scientists, and nurses, who collectively undertake clinical research involving many clinical disciplines, such as oncology, urology, ENT, pain management, audiology, and cardiology (http://www.betsiresearch.wales.nhs.uk/north-wales-clinical-research-centre-nwc). The research will be undertaken as part of collaboration between a mixture of basic scientists, with broad research experience, and clinicians, trained in oncology and genetics, from NWCRC, Cardiff University and Swansea University. During the course of the project there will be opportunities to undertake laboratory work in Swansea and/or Cardiff University (https://www.cardiff.ac.uk/medicine).

Eligibility

Academic requirements:

Candidates should have a 2.1 or above in their undergraduate degree a life science degree (such as Biochemistry or Biology, as examples), or a related subject. 

We would normally expect the academic and English Language requirements to be met by point of application. For details on the University’s English Language entry requirements, please visit – http://www.swansea.ac.uk/admissions/englishlanguagerequirements/

Residency criteria:

Due to funding restrictions, this scholarship is open to UK/EU candidates only.

For more information on eligibility please visit our website.

The scholarship covers the full cost of UK/EU tuition fees, plus a stipend. The bursary will be limited to a maximum of £14,483 p.a. dependent upon the applicant's financial circumstances.

There will also be additional funds available for research expenses.

   
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