Do you have a background in molecular, biochemical or chemical mechanisms yet are interested in translational medicine? Are you interested in taking your mechanistic findings rapidly to the bedside in a vigorous and internationally renowned clinical research program? If so, a postdoctoral fellowship position supported by the National Institutes of Health and the Prostate Cancer Foundation is available in the laboratory of Dr. Nima Sharifi at the Cleveland Clinic, Cleveland OH, USA.
Our laboratory focuses on mechanistic discovery to understand the metabolic and molecular mechanisms of androgen synthesis and androgen receptor gain-of-function that lead to resistance to hormonal therapy. Specific areas include:
We discovered the first example of a gain-of-function in a steroid-synthesizing enzyme that enables prostate cancer resistance to hormonal therapy (Chang, et al. Cell. 2013;154:1074-84). We also recently discovered that abiraterone works by conversion to a more active steroidal metabolite (Li, et al. Nature. 2015;523:347-51), that metabolism is pharmacologically modifiable to optimize therapy (Li, et al. Nature. 2016;533:547-51) and that these events are a class effect of steroidal androgen synthesis inhibitors (Alyamani, et al. Cell Chem Biol. 2017;24:825-32) and genetic determination of metabolite generation (Alyamani, et al. J Clin Invest. 2018;128:3333-40). View a quick summary of these discoveries here: http://www.youtube.com/watch?v=22dFzT4RFno
This position is ideal for an individual with a strong interest in rapid translation of basic mechanistic discoveries to the bedside as this is a principal goal of the Sharifi Laboratory. For example, we have shown that our discovery of a gain-of-function in a steroid-synthesizing enzyme is a predictive biomarker of poor outcomes after hormonal therapy (Hearn, et al. Lancet Oncol. 2016;17:1435-44; JAMA Oncol. 2018;4:558-62). We are currently evaluating this biomarker in an active clinical trial and are pursuing similar mechanisms and developing new treatment modalities based on these discoveries.
The position will provide a unique and multidisciplinary exposure to tumor metabolism, molecular oncology, drug development and clinical trials. Further details about our research and the interest it is generating are available at: http://www.lerner.ccf.org/cancerbio/sharifi/
The ideal candidate has a Ph.D. degree in biochemistry, chemistry or molecular biology; has the appropriate expertise in discovery of molecular, biochemical or chemical mechanisms; and is highly driven. Outstanding verbal and communication skills are required. Interested candidates should send their CV and contact information for 3 references to:
Nima Sharifi, M.D.
Kendrick Family Chair for Prostate Cancer Research
Director, GU Malignancies Research Center
|Location:||Cleveland - United States|
|Placed On:||9th January 2019|
|Expires:||9th March 2019|
Type / Role: