|Salary:||Competitive with benefits, subject to skills and experience|
|Placed On:||15th January 2019|
|Closes:||15th February 2019|
Location: The Francis Crick Institute, Midland Road, London
Contract: Full time, Fixed-term (4 years)
We seek two talented and highly motivated postdocs interested in investigating the interface between gene transcription, RNA metabolism and genome stability to join the Mechanisms of Transcription laboratory, led by Dr Jesper Svejstrup FRS. This group presently comprises three laboratory research scientists, nine postdoctoral fellows, and two students.
Dr Svejstrup’s laboratory focuses on various aspects of transcription-associated genome instability and the cellular response to transcription-obstructing DNA damage. Details of recent papers and research projects currently being undertaken can be seen at http://www.crick.ac.uk/research/a-z-researchers/researchers-p-s/jesper-svejstrup/.
Research techniques used in the laboratory include cell biology, biochemistry (including SILAC proteomics and reconstitution of key processes with purified factors in vitro) and modern genome-wide techniques (ChIP-Seq, RNA-Seq, GRO-Seq, etc), as well as genomic screening (siRNA and CRISPR screens).
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a brand new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under a single roof in Europe.
The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; to developing emerging talent and exporting it the rest of the UK; to public engagement; and to helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
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