Research topic: Synthesis of Substrates for Biocatalytic Oxidation, and Characterisation and Elaboration of the Products
Division: Environment and Biotechnology (Molecular Science Group)
Reporting to: Professor Jeremy Robertson
Contract type: Fixed-term (3 years), with the possibility of extension
Start date: 1 June 2019
Additional information: Synthetic organic chemistry, compound purification, and spectroscopic analysis
The OSCAR research scientists (RSs) in organic synthesis will be part of a team investigating selective oxidation of organic compounds by engineered variants of cytochrome P450 enzymes for applications in the synthesis of high-value intermediates and active ingredients for the agrochemical and pharmaceutical industries. The posts are tenable for three years starting 1 June 2019. The RSs will report to Professor Jeremy Robertson, the joint-PI (with Professor Luet Wong) of the programme.
The RSs will join the effort to prepare small-molecule substrates for regio- and stereoselective C–H bond oxidation by enzyme mutants. Following screening (usually by a collaborating RS), the RSs will isolate and characterise the major oxidised products from scaled-up reactions using a combination of standard analytical techniques, primarily nuclear magnetic resonance spectroscopy and mass spectrometry. Isolated, characterised products will provide reference samples for further screening rounds, intermediates for further elaboration to targets of interest, and new potential components of pharmaceutical and agrochemical screening libraries. The RSs will have sufficient experience to design effective and scalable synthetic strategies and protecting group regimes to produce appropriate substrates in a timely fashion. The RSs will have a supervisory role and work with research technicians (RTs) supporting the programme. The ability and willingness to participate in technology transfer to industrial partners is essential.
The project requires two RS in the first instance to develop the use of C–H hydroxylating enzymes for a variety of synthetic chemistry applications. Applicants should have significant expertise in organic synthesis with a demonstrated ability to design and execute multistep routes to structurally-diverse and stereochemically defined organic molecules; extensive expertise in compound isolation, purification, and spectroscopic analysis (especially NMR) will be essential. Applicants should have a PhD in synthetic organic chemistry, or should have submitted a PhD thesis in this area prior to taking up the appointment. Further details are available for download here and informal enquiries may be made to Professor Robertson via email: firstname.lastname@example.org.
This is an exciting opportunity to establish and develop research activities in brand new laboratories fully-equipped and resourced for synthetic biology, organic synthesis, and materials chemistry. The work will be done in collaboration with research groups in Oxford and there will be the opportunity to undertake 1–2-month research visits there.
OSCAR was created as a partnership between the University of Oxford and the Suzhou Industrial Park www.sipac.gov.cn/english/. The building comprises 20,000 m2 of space distributed over nine floors and will house translational collaborative research originating from twelve academic research groups from the University of Oxford’s Departments of Chemistry, Engineering Science, and Materials. Researchers in the Molecular Science Group (PIs: Moloney, Robertson, Wong) have dedicated brand new office and laboratory space, with adjacent analytical and spectroscopic equipment, including 400 MHz NMR, IR, UV, GC, analytical and preparative SFC-MS, GPC, and surface analytical and processing instrumentation. Further details and an image gallery are available at oscar.web.ox.ac.uk.
How to apply
Applicants should submit a covering letter and CV in English as a PDF attachment by email to email@example.com before the closing date of 12:00 midday on 29th March 2019. The email subject should specify the title of the post for which you are applying and you must include your full name and telephone number.
|Location:||Suzhou - China|
|Salary:||A competitive remuneration package will apply.|
|Placed On:||28th January 2019|
|Closes:||29th March 2019|
Type / Role: