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Postdoctoral Research Associate

Imperial College London - Division of Infectious Diseases/Department of Medicine/Faculty of Medicine

Location: London
Salary: £37,904 to £40,994 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 23rd January 2019
Closes: 24th February 2019
Job Ref: MED01024
 

An exciting opportunity has arisen for a postdoctoral Research Associate in the Section of Virology within the Division of Infectious Diseases, Department of Medicine at Imperial College London.

You will join a leading research group headed by Professor CRM Bangham, carrying out research on the cellular immune response, virology and cell biology of infection with the human T-cell leukaemia virus type, HTLV-1. 

The new project is a collaboration with Prof. M. Katan, University College London; the available position in Imperial is funded by grants from the Medical Research Council and the Wellcome Trust. The aim of the project is to investigate the acquisition and impact of mutations in the phospholipase C-gamma 1 (PLCg1) gene in individuals infected with HTLV-1: these mutations can lead to malignant transformation of the infected T-cell, resulting in the devastating condition called adult T-cell leukaemia/lymphoma (ATL).  Individuals with expertise in molecular techniques and T-cell biology are particularly encouraged to apply.

You will learn and carry out targeted gene editing of primary human T-lymphocyte clones by transfection of CRISPR/Cas9 ribonucleoprotein, using a protocol that is in use in this laboratory. You will investigate the impact of these mutations on the growth, gene expression and function of T lymphocytes in vitro.

You must have a PhD or equivalent in virology, immunology or a closely related discipline. Successful research experience in HTLV-1 infection or a similar field, including publications in reputable journals, is essential.

The post is available for eighteen months, to start as soon as possible. The contract is subject to the normal terms and conditions of employment in Imperial College.

Closing date: 24 February 2019

Imperial Expectations guide the behaviour of all our staff.

Should you have any queries please contact:

For administrative details: Ms Michelle Kiely – m.kiely@imperial.ac.uk

For details on the project: Prof Charles Bangham – c.bangham@imperial.ac.uk

Committed to equality and valuing diversity, we are also an Athena SWAN Silver Award winner, a Stonewall Diversity Champion, a Disability Confident Employer and are working in partnership with GIRES to promote respect for trans people.

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

   
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