|Location:||Newcastle upon Tyne|
|Funding for:||UK Students, EU Students, International Students|
|Funding amount:||UK/EU tuition fees paid and annual living expenses of £15,009 (full award)|
|Placed On:||6th March 2019|
|Closes:||15th May 2019|
Value of award
100% of UK/EU tuition fees paid and annual living expenses of £15,009 (full award). Successful international candidates will be required to make up the difference between the UK/EU fees and international fees.
Number of awards
Start date and duration
23 September 2019 for 3 years.
Application closing date
15 May 2019.
Do you want to work in one of the hottest fields in microbiology and are you interested in how our microbiota functions and contributes to human health? This project will advance our understanding how keystone Gram-negative members of the human microbiota acquire iron. Iron is an essential element for all forms of life due to its important role in many enzymes and metabolic processes. However, the bioavailability of iron is very limited due to its low solubility and the ability of the free metal to generate harmful reactive oxygen species. For this reason, bacteria have evolved sophisticated mechanisms to acquire iron, for example from their host. One example in the gut bacterium Bacteroides thetaiotaomicron and the oral pathogen Porphyromonas gingivalis is the hemophore HmuY, which is a cell surface protein that binds heme via a novel mechanism and most likely transfers it to the co-transcribed HmuR membrane transporter for uptake across the outer membrane.
The structure of the HmuYR complex, and consequently the way it functions, are not known. This project will aim to solve the structure of the HmuYR complex from in order to understand how the two proteins function in concert to acquire iron and contribute to the fitness of the bacteria in their highly competitive environments. The work is highly multidisciplinary and will involve X-ray crystallography and potentially cryo-EM, ligand-binding techniques such as microscale thermophoresis and isothermal titration calorimetry as well as a range of microbiological techniques and membrane protein biochemistry.
Name of supervisor(s)
You must have, or expect to achieve, at least a 2:1 Honours degree in biomedicine, physiology, microbiology or a related area. A further qualification such as an MSc or MRes is advantageous.
This award is available to UK/EU and international applicants.
To study this course you need to meet the following English Language requirements: IELTS 6.5 overall (with a minimum of 5.5 in all other sub-skills).
How to apply
You must apply through the University’s online postgraduate application system. To do this please ‘Create a new account’.
Only mandatory fields need to be completed. However, you will need to include the following information:
Type / Role: