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Novel approaches for imaging nucleic acids in the cell

University of Birmingham - School of Chemistry

Qualification Type: PhD
Location: Birmingham
Funding for: UK Students, EU Students
Funding amount: Not Specified
Hours: Full Time
Placed On: 12th March 2019
Closes: 10th June 2019

Applications are invited for a PhD studentship with the Neely group, School of Chemistry, University of Birmingham.

Work in the group focusses on imaging of the DNA molecule and this PhD will build on our work using the DNA methyltransferases to target specific DNA sequences for labelling and analysis. We are particularly interested in extending these approaches to enable three-dimensional imaging of nucleic acids within the cell.

The project will focus on the application and development of chemical biology for targeting nucleic acids. This will encompass synthesis of cofactor analogues for the DNA methyltransferase enzymes, their application for DNA labelling and study using state-of-the-art optical microscopies. The group holds expertise in all of these areas and the successful candidate will receive appropriate training during their PhD.

The project aims to develop new understanding of the spatial organization of nucleic acids in the cell and its relationship to disease.

Applicants are not expected to have initially the expertise to cover all aspects of the project. However, candidates must have a degree in chemistry, physics or a relevant, related discipline at the upper second class level and bring an interest in microscopy and an enthusiasm for learning to the group.

More information on our current work can be found at the group website or by contacting Dr Rob Neely directly.

A scholarship to cover University fees and provide 36 months maintenance at standard RCUK rates is provisionally available for applicants who are UK/EU nationals and hold or obtain a minimum of a good (>65%) upper second class or higher integrated UK masters (MSci/MChem) degree or equivalent in chemistry or a related subject. Students with a combination of a good UK or equivalent BSc degree followed by an MSc with >60% in all taught elements will also qualify.

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