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Imaging Mass Spectrometrist

European Molecular Biology Laboratory (EMBL)

Location: Heidelberg - Germany
Salary: Grade 4, 5 or 6, depending on experience and qualifications.
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 16th May 2019
Closes: 7th July 2019
Job Ref: HD01538

About the team/job

The European Molecular Biology Laboratory (EMBL), one of the highest ranked scientific research organizations in the world, is looking for an Imaging Mass Spectrometrist, a staff member who will actively participate in the development, evaluation, optimization, and application of MALDI-imaging mass spectrometry methods. This position is open in the Alexandrov Team within the ERC Consolidator project METACELL on spatial single-cell metabolomics as well as an OpenTargets project ( on investigating metabolism of immune cells in collaboration with other groups at EMBL, the Wellcome Sanger Institute, Sanofi and other companies including Celgene, GSK, and Takeda.

Your role

Your responsibilities will include developing, optimizing, evaluating MALDI-imaging mass spectrometry methods on a cutting-edge MALDI-imaging system (AP-SMALDI2-Orbitrap with 2 μm pixel size) and applying them in particular to immune human cells. You will also be engaged in interdisciplinary work together with data scientists and software developers to improve METACELL, METASPACE and other software tools and platforms developed by the Alexandrov Team. In the framework of the ERC and OpenTargets projects, you will collaborate with other scientists internally at EMBL and externally, in particular at Wellcome Sanger, on integrating MALDI-imaging with cutting-edge single-cell technologies, including RNA-seq and metabolomics. 

You have

We are looking for a university graduate with a degree in Analytical Chemistry or related disciplines. Essential qualifications include experience in imaging mass spectrometry for metabolites, small molecules and/or lipids. Willingness to work in a small highly-interdisciplinary team is required. 

You might also have

Having one of the following would be a plus: proficiency specifically in MALDI-imaging mass spectrometry and/or using Orbitrap-HRMS for non-spatial metabolomics; knowledge of mammalian metabolism and/or experience of working with mammalian cells; hands-on experience in brightfield and fluorescent microscopy. The basic knowledge of programming or scripting is helpful but not required immediately.  

Why join us

You will be a critical part of a dynamic, interdisciplinary, international and cross-cultural team where we work at the intersection of biology, chemistry, and computer science. Our team currently includes 7 scientists and 3 software developers. We develop integrative computational and experimental methods for spatial metabolomics to detect metabolites in tissues and cells and interpret this molecular data in light of the spatial context. We strive to provide a healthy work environment with a flat hierarchy supporting a diversity of opinions, with freedom to make decisions and with funded opportunities to grow professionally.

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