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PhD Studentship: Development of Native Liquid Extraction Surface Analysis Mass Spectrometry for Drug Discovery

University of Birmingham - School of Biosciences

Qualification Type: PhD
Location: Birmingham
Funding for: UK Students, EU Students
Funding amount: £15,009 per annum, see advert for details
Hours: Full Time
Placed On: 6th June 2019
Closes: 31st August 2019

A fully-funded 4-year PhD studentship is available within the School of Biosciences at the University of Birmingham, in collaboration with AstraZeneca.

The project will develop an in situ tool for structural characterisation of protein/protein and protein/drug complexes. The principal aim is to develop native liquid extraction surface analysis mass spectrometry to support drug discovery by combining native mass spectrometry, in which proteins remain in their folded form and their intra- and intermolecular non-covalent interactions are maintained in the gas-phase, and liquid extraction surface analysis, in which biological substrates are directly sampled.

The PhD will provide specialist training in advanced mass spectrometry techniques, ambient surface mass spectrometry, ion mobility spectrometry, and liquid chromatography. The PhD will also provide transferable skills acquired through the comprehensive training provided by the Biosciences Graduate Research School.

We seek an exceptional candidate with an undergraduate or Masters degree in chemistry or biochemistry. Start date will be Oct 2019.

Informal enquiries may be addressed to Prof Helen Cooper at h.j.cooper@bham.ac.uk.  For further details on the research in the Cooper laboratory, including relevant research papers, visit: www.biosciences-labs.bham.ac.uk/cooper

How to apply?

Please apply through the University of Birmingham application portal through the ‘Apply to Study Here’ link found at

http://www.birmingham.ac.uk/postgraduate/courses/research/bio/biosciences.aspx 

When applying, specifically include the project title.

Eligibility: This is a fully funded studentship available to UK nationals (or EU nationals who have been resident in the UK for 3 years).

Closing Date: Applications accepted year round

   
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