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PhD Studentship - Modulation of Bioactive Peptides via a Combination of Synthetic and Computational Chemistry Methods

University of Sussex - Chemistry

Qualification Type: PhD
Location: Falmer
Funding for: UK Students, EU Students
Funding amount: Not Specified
Hours: Full Time
Placed On: 7th June 2019
Closes: 1st July 2019

A Ph.D. studentship (42 months) is available from September under the supervision of Dr. Cristina Pubill Ulldemolins, Department of Chemistry, School of Life Sciences.

Our multidisciplinary research group focuses on the use of experimental and computational approaches to design new bioactive peptides as novel therapeutic leads for the treatment of Alzheimer’s Disease and cancer.

Our trans-disciplinary research, performed in collaboration with neuroscientists at St Andrews University, is at the frontiers of biology, chemistry and computational science and aims to tackle the shortcomings of the extant peptide-based therapeutics, thereby bringing this technology closer to robust in vivo implementation, and, therefore, closer to clinical trials.

The current project aims to develop our catalytic methodologies to generate analogues of bioactive peptides in an efficient and sustainable manner. These peptides will be subjected to biological assays to fully explore and establish their structure–activity relationships.

This PhD will enable the successful candidate to acquire a broad range of skills in general synthetic chemistry (the development of catalytic methods in particular), as well as in computational modelling and the design of peptides and their evaluation via bioassays.

Please submit a formal application using our online application system at www.sussex.ac.uk/study/phd/apply, including a CV, degree transcripts and certificates, statement of interest and names of two academic referees.

On the application system use Programme of Study – PhD Chemistry.

Please make sure you include the project title and Supervisor’s name with your statement of interest on the application form.

This School funded position, which covers fees and a stipend at standard RCUK rates, is open to Home/EU applicants. Ideal candidates will have a strong background in synthetic chemistry, catalysis and analytical techniques such as NMR spectroscopy; additional experience in computational chemistry would be advantageous. Eligible applicants will have recently received an MSc and/or a First or high 2:1 BSc in a relevant subject. Candidates for whom English is not their first language will require an IELTS score of 6.5 overall, with not less than 6.0 in any section.

Contact Emma Chorley for application enquiries (elc38@sussex.ac.uk).

Contact Dr. Pubill-Ulldemolins (C.Pubill-Ulldemolins@sussex.ac.uk) for enquiries about the project

   
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