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MRC Postdoctoral Fellow

University of Cambridge - MRC Toxicology Unit

Location: Cambridge
Salary: £32,236 to £39,609
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 17th June 2019
Closes: 21st July 2019
Job Ref: PU19573
 

The Medical Research Council Toxicology Unit is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease. The Unit is equipped with state-of-the-art facilities including super resolution microscopy and offers excellent opportunities for postdoctoral development. The Unit is part of the University of Cambridge; it is currently located at Leicester and will physically relocate to Cambridge in 2020, therefore the first part of the project will be conducted at Leicester. 

Applications are invited for an MRC Postdoctoral Fellow (PF) to join the laboratories of Willis and MacFarlane within the Unit's Cross-Unit Programme: Mechanisms of Fibre Toxicity. The focus of the programme is to carry out research into the molecular pathways triggered by exposure to toxic fibres that leads to mesothelioma, for further information visit: https://www.mrc-tox.cam.ac.uk/research/mechanisms-fibre-toxicity 

The aim of the project is to generate a detailed adverse outcome/toxicity pathway which fully describes in molecular terms the changes which lead to the development of MPM following exposure of mice to CNTs with different aspect-ratios and chemically-modified fibres. In the longer term, this information will be used to obtain novel biomarkers of exposure to monitor workers in facilities which use/produce CNTs (including low and middle income countries, LMICS). It will also inform about the potential hazards associated with the use of new nanofibres and promote the concept of "safe by design" to those developing such materials. The project will identify the contribution of dysregulated transcription, and translation, RNA-interactome to adverse events that follow nanofibre exposure. 

This is a three year training and development position.  We support postdoctoral scientists in these positions with a range of formal and on-the-job training to ensure you receive the training relevant to your role and identify additional training to help support your future career.  

Applicants must have (or be in the final stages of receiving) a PhD in a relevant discipline and have experience in molecular and cell biology. Experience in RNA biology, epigenetics, transcription profiling, cancer cell biology and working with animal models is desirable. The ability to publish high quality research in a peer reviewed journal; to be able to work both independently and as part of a team, together with excellent communication and problem solving skills are required. 

Further information on the Toxicology Unit can be found at https://www.mrc-tox.cam.ac.uk/ 

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a security check. 

To apply online for this vacancy and to view further information about the role, please visit :

http://www.jobs.cam.ac.uk/job/22013

Informal enquiries can be directed to Anne Willis at aew80@cam.ac.uk

If you have any queries regarding the application process please contact Rebecca Heatherley at rsh49@mrc-tox.cam.ac.uk 

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a security check. 

Please quote reference PU19573 on your application and in any correspondence about this vacancy. 

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. 

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

   
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