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Research Fellow

University of Birmingham - Cancer and Genomic Sciences College of Medical and Dental Sciences

Location: Birmingham
Salary: £30,395 to £39,609 With potential progression once in post to £42,036 a year (Grade 7)
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 23rd August 2019
Closes: 22nd September 2019
Job Ref: 81992

Duration Fixed Term Contract to 31 August 2022

Applications are invited for two highly motivated and organised post-doctoral research fellows to join the Stewart laboratory, based at the University of Birmingham, to work on understanding how inherited deficiencies in components of the DNA damage response, particularly proteins involved in DNA repair and/or DNA replication, contribute to the development of human disease (for examples see: Ogi  et al (2012) PLoS Genet 8:e1002945; Murray  et al (2015) Am J Hum Genet 96:412-24; Harley et al (2016) Nat Genet 48:36-43; Byrd  et al (2016) PLoS Genet 12:e1005945).

Ongoing research projects within the laboratory focus on characterising the impact of patient-associated mutations in known DNA repair/replication genes on genome stability, the identification of novel human disease genes associated with defective DNA repair/replication and identifying roles for previously uncharacterised genes/proteins in the DNA damage response (for example: Higgs et al (2015) Mol Cell 59:462-77).

Candidates will be expected to undertake novel, cutting-edge, laboratory-based research within the field of the DNA damage response and replication, specified within a CR-UK funded research programme.

Some of the key duties with include:

  • To plan and develop research activity as outlined in the grant proposal as well as novel research directions, with assistance of a mentor if required.
    • To contribute to writing grant applications for research funding
    • Critically review grant applications and research publications
    • Analyse and interpret the results of own research and generate original ideas based on outcomes
    • Design a successful programme of investigation, managing individual components of the study from the start of the project to dissemination of findings within set timeframes
    • Evaluate methods and techniques used and results obtained by other researchers and relate such evaluations appropriately to your own work
    • Present research results through publication or other recognised forms of output, e.g. peer-reviewed journals, reports and conference presentations at a national/international level  

The successful candidate will have:

  • Ph.D. and previous experience within the field of DNA damage signalling, DNA repair and/or DNA replication
    • At least 1 first author publication in a peer-reviewed scientific journal
    • Practical experience with in vitro mammalian cell (including making retrovirus and lentiviruses, generating stable cell lines)
    • Practical experience with microscopy-based laboratory techniques (including immunofluorescence, chromosome breakage analysis)
    • Practical experience with recombinant protein expression and purification, Western blotting and immunoprecipitation
    • Practical experience with molecular biology (including primer design, RT-PCR, DNA/RNA isolation, cloning, DNA sequencing, expression plasmid generation, CRISPR technology)
    • Practical experience with DNA and siRNA transfection
    • Practical experience with DNA fibre analysis/DNA combing

For informal enquiries, please contact Prof. Grant Stewart (g.s.stewart@bham.ac.uk)

To download the full job description and details of this position and submit an electronic application online please click on the Apply Online button below or visit www.hr.bham.ac.uk/jobs  Please quote Job Ref 81992 in all enquiries.

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