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Research Associate

Imperial College London

Location: London
Salary: £38,566 to £47,579 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 23rd August 2019
Closes: 30th September 2019
Job Ref: MED01403
 

Location: South Kensington Campus

We are seeking a highly motivated Postdoctoral Research Associate to work in the Section of Molecular Microbiology, which is part of the Centre for Molecular Bacteriology and Infection (CMBI) at Imperial College London. The position is funded through the Wellcome Trust.

Duties and responsibilities

The research project will focus on the Gram-positive bacterial pathogen Staphylococcus aureus and the work will be conducted in the state-of-the-art laboratory of Professor Angelika Gründling. The research programme will focus on understanding cellular processes that are controlled by the essential signalling nucleotide c-di-AMP in S. aureus with the long-term goal to use this knowledge to develop new methods to prevent the growth, colonization and infection with this organism. c-di-AMP is a more discovered signalling nucleotide required for the growth of S. aureus under standard growth conditions and plays an important role in osmotic regulation and cell wall homeostasis. Methicillin resistant S. aureus (MRSA) strains producing reduced levels of c-di-AMP become again sensitive to beta-lactam antibiotics.

The reason for this is currently not known and this project will focus on deciphering the molecular bases for this. It is anticipated that some of this work will require a biochemical analysis of the cell wall as well as RNA-Seq analysis of WT and mutant bacteria. Recent work from the lab has shown that while c-di-AMP is essential for growth under aerobic growth conditions, it becomes dispensable under anaerobic conditions.

A second project will focus on investigating metabolic changes that occur when S. aureus growths aerobically versus anaerobically as well as provide a better understanding of essential genes under aerobic versus anaerobic growth conditions. The latter project will be done using amongst others the Tn-seq methodology.

Essential requirements

You will have a PhD (or be in the final stages of completion) or equivalent in Microbiology, Molecular Biology, Biochemistry or a related field. You will also have knowledge in the genetic manipulation of bacteria and previous experience working with Gram-positive bacteria is desirable. You will have a proven track record in the computational analysis of high through put data such as Tn-Seq or RNA-Seq data and experience with Python or similar programming languages. You will also have experience within an academic research environment and a proven track record with publication in relevant and peer reviewed high-quality journals.

Further information

This role is full-time, fixed-term for two years with possibility of extension to four years.

Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £35,477 - £38,566 per annum.

Interviews are expected to be held early October 2019.

For more information about the role, please contact Prof. Angelika Grundling at  a.grundling@imperial.ac.uk

For technical issues when applying online please email recruitment@imperial.ac.uk

Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.

Closing date: 30/09/2019

To apply, visit www.imperial.ac.uk/jobs and search by the job reference MED01403.

   
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