Back to search results

PhD Studentship: How Does the Brain Make Decisions When Faced with Conflicting Options?

University of Birmingham - School of Biosciences

Qualification Type: PhD
Location: Birmingham
Funding for: UK Students, EU Students
Funding amount: Not Specified
Hours: Full Time
Placed On: 22nd November 2019
Closes: 6th January 2020

Animals engage in daily activities that are essential for survival and reproduction, such as feeding, mating or fighting for resources. How does an animal prioritise one behaviour over others? We know that cues conveying external information (e.g., threats from other animals, access to food) and internal state (e.g., fear, hunger, tiredness) guide behavioural choices. However, exactly how action-selection occurs in the brain remains unknown.

This research proposal aims to understand how the brain makes decisions when faced with conflicting options using the fruit fly model, Drosophila melanogaster.

Fruit flies exhibit complex behaviours that are controlled by a relatively small brain. Furthermore, sophisticated genetic tools are available which facilitate the control of individual neurons with temporal resolution, enabling us to probe the circuitry underlying behaviour.

Using Drosophila as a model system provides a unique opportunity to address fundamental aspects of action selection: how does the brain integrate information from the outside world and internal state to select the most appropriate action for each situation? What neurons and mechanisms underlie these behavioural decisions?

To address these questions, the PhD student will use a range of cutting-edge techniques:

  • Genetics
  • Confocal microscopy
  • Optogenetics
  • Thermogenetics
  • Molecular biology
  • Behavioural assays
  • Live imaging

To record neural activity in behaving flies, we will collaborate with research groups at Oxford University and Tel Aviv University.

Significance

How the brain selects appropriate actions is a fascinating question that remains unknown. Choosing appropriate actions is not only crucial for our life but can, collectively, influence the course of our society. Furthermore, action-selection processes are impaired in addiction and neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease. Understanding how different neurons contribute to optimal action-selection in a genetically tractable experimental system will help us advance our knowledge of how the brain works, and what goes wrong in disease.

Informal enquiries about the post should be directed to Dr Carolina Rezaval C.Rezaval@bham.ac.uk 

For information about research in our laboratory, please visit our lab webpage:
https://www.rezavallab.org

University webpage: https://www.birmingham.ac.uk/staff/profiles/biosciences/rezaval-carolina.aspx

Watch a 3-minute video about Dr Rezaval’s past work: https://vimeo.com/177551510

You can apply for a 4 year BBSRC-funded doctoral fellowship (MIBTP): View Website.
Eligibility: UK/EU nationals, residence in the UK is NOT a pre-requisite.

To apply please generate an account: View Website
and select our project. View Website

Deadline: January, 6th. Please, contact me for more info: C.Rezaval@bham.ac.uk 

We encourage applications at any time from students able to find their own funding or who wish to apply for their own funding.

   
We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Subject Area(s):

Location(s):

PhD tools
 
 
 
 
More PhDs from University of Birmingham

Show all PhDs for this organisation …

More PhDs like this
Join in and follow us

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge