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Research Fellow: Signalling Mechanisms Controlling Synaptic Plasticity in Health and Disease

UCL - Division of Biosciences

Location: London
Salary: £35,965 to £43,470 Grade 7, Per annum, Inclusive of London Allowance
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 2nd December 2019
Closes: 31st January 2020
Job Ref: 1847586

The appointment will be on UCL Grade 7. The salary range will be £35,965 - £43,470 per annum, inclusive of London Allowance.

Applications are invited for a Research Fellow to study the cellular and molecular mechanisms that regulate synaptic plasticity in the mammalian nervous system. The successful applicant will study the mechanisms by which Wnt signalling regulates synaptic plasticity in the hippocampus through specific Frizzled receptors (McLeod et al, Cell Reports 2018). The Research Fellow, under the direction of Professor Patricia Salinas at UCL, will take a multidisciplinary approach that combines in vivo analyses of mutant mice using state-of-the-art imaging techniques combined with the latest biochemical and proteomic methods, optogenetics and electrophysiology. The researcher will also examine how Wnt-mediated synaptic plasticity influences synapse stability in the context of neurodegenerative diseases. 

We are interested in attracting enthusiastic scientists with expertise in the following areas: cellular neurobiology, biochemistry and imaging analyses. Knowledge of electrophysiology is desirable.

The post, funded by the MRC, will be awarded for one year in the first instance with the possibility of further funding.

PhD (or be finishing it) in a relevant subject area is essential, note candidates must have submitted their thesis by the time of the interview. Proven knowledge of research techniques and methodologies such as cellular neurobiology, biochemistry and cell imaging is essential as well as demonstrable comprehensive knowledge in the subject area of cellular neurobiology.

Please note: Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at research assistant Grade 6B (Salary £31,479 - £33,194 per annum, including London Allowance) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis (including corrections).

Applicants should apply online. To access further details about the position and how to apply please click on the ‘Apply’ button above.

For informal enquiries about the post please contact Professor Patricia Salinas at

If you have any queries regarding the application process please contact Biosciences staffing on quoting the vacancy reference number: 1847586.

Latest time for the submission of applications: 23.59.

UCL Taking Action for Equality.

We will consider applications to work on a part-time, flexible and job share basis wherever possible.

Our department holds an Athena SWAN Bronze award, in recognition of our commitment to advancing gender equality.

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