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Research Associate in Antibody Discovery for Neurodegeneration

Imperial College London - Department of Chemistry, Faculty of Natural Sciences

Location: London
Salary: £40,215 to £47,579 per nanum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 29th January 2020
Closes: 1st March 2020
Job Ref: NAT00648

Location: White City Campus, London

Applications are invited for a postdoctoral researcher in antibody discovery to join the Aprile group at the Department of Chemistry of Imperial College London.

Antibodies are powerful biomolecules, which find a wide application in research and clinic. The research of the Aprile group is focused on the development of antibody-based tools to study neurodegeneration. In particular, the Aprile group is interested in developing and using antibodies to understand the mechanisms of formation and toxicity of pathological protein aggregates called amyloids.

Duties and responsibilities

You will play a key role in the development of novel directed evolution technologies to generate antibodies as inhibitors of amyloid aggregation. You will also produce these antibodies (using cloning, expression, and purification techniques) and characterise their binding and stabilities.

Essential requirements

  • PhD in a relevant STEM discipline
  • A strong background in biochemistry and molecular biology
  • Experience in directed evolution, preferably cell-free techniques, and a strong interest in chemical biology
  • Experience in antibody-based detection assays (i.e. ELISA)
  • A highly motivated individual with excellent communication skills, able to work effectively as part of a multi-disciplinary team.

Further Information

Contract: 1-year fixed term initially, with possible extension of up to 1 year.

Should you require any further details on the role please contact: Francesco Aprile,

Candidates who have not yet been officially awarded their PhD will be appointed as Research Assistant within the salary range £35,477- £38,566 per annum

For technical issues when applying online please email

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level.

Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.

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