|Salary:||Competitive with benefits, subject to skills and experience|
|Placed On:||18th September 2020|
|Closes:||30th October 2020|
Contract: Fixed-term (4 years)
A postdoctoral position is available in the laboratory of Dr. Rashmi Priya at the Francis Crick institute.
Dr Priya’s laboratory focuses on the mechano-molecular control of organ development during embryogenesis. For a brief overview of the lab, please visit https://www.crick.ac.uk/research/labs/rashmi-priya or get in touch with Dr. Priya.
The Francis Crick is a modern, world class biomedical research institute in central London. The successful candidate will be part of a highly inclusive, collaborative and thriving research community. We have generous core-funding support and access to the state-of-the-art facilities and technology platforms including Advanced light microscopy, High throughput sequencing, Bioinformatics and image analysis help desk.
I am especially looking for candidates who are interested in combining interdisciplinary approaches to gain a systemic understanding of organ morphogenesis using a well-suited model system – the developing zebrafish heart. The suitable candidate will use advanced microscopic techniques, image analysis, genetic/optical manipulations, biophysical approaches and collaborate with theoreticians to understand how morphological and molecular complexity emerges during heart development.
Heart is the first organ to form and function during embryonic development. A critical step during vertebrate heart development is trabeculation, during which the myocardial wall transforms from a monolayer to a complex structure consisting of two distinct cell types: outer compact layer and inner trabecular layer cardiomyocytes. How this topological complexity is achieved and what are the underlying mechanisms that shape these crucial anatomical structures remain unknown.
The project will aim to unravel the underlying mechanical, molecular and geometric interactions that transforms a developing heart from a simple epithelium into a highly intricate patterned organ. Candidates with a strong back ground in advanced confocal and/or light sheet imaging, image analysis, zebrafish genetics and a good understanding of the mechanics of tissue morphogenesis and/or heart development are encouraged to apply. The successful candidate should be keen in pursuing collaborative research, should have excellent communication skills and should be a good team player.
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.
The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
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