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Project Research Scientist

The Francis Crick Institute

Location: London
Salary: Competitive with benefits, subject to skills and experience
Hours: Full Time
Contract Type: Permanent
Placed On: 16th October 2020
Closes: 16th November 2020
Job Ref: 15088
 

Short summary

We are seeking a highly motivated and collaborative postdoc in the area of human embryology and stem cell biology to join Professor Kathy Niakan’s laboratory.

The aim of the project is to characterise early lineage specification in early human embryos. We have recently identified several transcription factors and components of key signaling pathways that are highly expressed in epiblast cells of the developing human embryo, which we hypothesize may have an important function for the development of these pluripotent cells. We seek to understand the function requirement of these factors using a range of methods including cutting-edge single cell, imaging and genome editing techniques. Ultimately, this knowledge will provide fundamental insights into human biology and facilitate the development of conditions for the further refinement of implantation models and the establishment of novel human stem cells and stem cell-based models of development.

We seek candidates who are energetic, focused, and productive with a desire to work in a congenial, dynamic, and collaborative research environment. Good organisational, analytical, and communication skills are essential.

Project scope

Dr Niakan’s laboratory focuses on understanding the mechanisms of lineage specification in human embryos and the derivation of novel human stem cells. Details of research projects currently being undertaken can be seen at:  http://www.crick.ac.uk/kathy-niakan

Research techniques used in the laboratory include: molecular biology, advanced microscopy and image quantification, human and mouse preimplantation embryo culture and micromanipulation, genome modification, genome-wide techniques including single-cell RNA-sequencing, multi-omics analysis and human trophoblast, embryonic and induced pluripotent stem cell derivation.

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute is world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

  • The closing date for applications is 16 November 2020 at 23:45.
  • All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.
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