PhD Studentship: Protein Origami: New Computational Methods to Predict Protein Folding Ensembles

The EPSRC Centre for Doctoral Training in Modelling of Heterogeneous Systems (HetSys) training programme is designed to enable students to become high-quality computational scientists who are comfortable working in interdisciplinary environments, have excellent communication skills, and are well prepared for a wide range of future careers in areas where there is demonstrable need.

The four-year training programme consists of PhD project and integrated taught modules, leading to the award of a postgraduate diploma.

We are looking for enthusiastic students from across the physical sciences who enjoy using their mathematical skills and thinking flexibly to solve complex problems. We require at least a 2(i) honours degree at BSc or an integrated masters degree (e.g. MPhys, MChem, MSci, MEng etc.) in a physical sciences, mathematics or engineering discipline.

https://warwick.ac.uk/fac/sci/hetsys/projects/2021/

Protein origami: New computational methods to predict protein folding ensembles

How does a protein fold into its native state? This is one of the most important and challenging problems in the chemical sciences, and a key question in understanding diseases driven by protein misfolding and aggregation (such as Parkinson’s disease). In this project, we will develop and employ a new computational scheme to access long time-scale protein folding events by mapping onto a discretized connectivity-based description of protein structure. This new approach will then enable us to investigate sequence-specific folding effects and translational folding, as well as providing a new scheme for protein-structure prediction.

Funding Details

HetSys provides funding for the four-year programme to UK students.

We expect a small number of fully funded international places to be available on a competitive basis to exceptional students of any citizenship. Applications must be submitted by 21 January 2021.

Please see the website for further information: https://warwick.ac.uk/fac/sci/hetsys/apply/

The studentships pay a stipend to cover maintenance as well as paying the university fees and research training support. The stipend is at the standard UKRI rate (for 2020/21 that is £15,285 per annum).

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