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Postdoctoral Scientist

University of Oxford - MRC Oxford Institute for Radiation Oncology

Location: Oxford
Salary: £32,817 to £40,322 Grade 7
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 14th January 2021
Closes: 1st February 2021
Job Ref: 149009
MRC Oxford Institute for Radiation Oncology, Department of Oncology, Old Road Campus Research Building, Headington, Oxford, OX3 7DQ

Grade 7: in the range of £32,817 to £40,322

Please Note: this is a re-advertisement. Previous applicants need not apply.

Radiotherapy kills tumour cells by both generating lethal DNA damage and by triggering immunogenic cell death, yet how these radiation responses are coordinated is poorly understood. The role of the job will be to explore this relationship to enable improved RT treatments through enhancing the immune response. 

The position is funded by RadNet, a CRUK funded initiative to promote Radiation Research networking, and will be embedded within an active research team, run by Dr Timothy Humphrey within the MRC Oxford Institute for Radiation Oncology, with close links with the RadNet Immunopeptidomics Core, run by Dr Nicola Ternette (Nuffield Department of Medicine) at the University of Oxford. 

The postholder will undertake research into the impact of modulating the DNA damage response on radiation-induced neoantigen formation, testing hypotheses and analysing scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate. You will adapt existing and develop new scientific techniques and experimental protocols. The successful applicant will be expected to work both independently and as part of a team, assisting with the supervision of students as required. You will publish your results in a timely manner and present your work at lab meetings and also nationally/ internationally. 

The successful candidate will hold, or be close to completing, a PhD/DPhil in Molecular Biology, Immunology or related subject. You will need a strong knowledge of the DNA damage response and immunology and have previous experience of contributing to publications and presentations. The ability to manage your own academic research and associated activities is essential. 

This is a full-time post, fixed term until 31 March 2022. An early start date is essential.

The post will be based at the Department of Oncology, MRC Oxford Institute for Radiation Oncology, Old Road Campus Research Building, off Roosevelt Drive, Headington, Oxford, OX3 7DQ.

You will be required to upload a supporting statement and CV as part of your online application.

The closing date for applications is 12.00 midday UK time on Monday 01 February 2021

Closing Date: 01-FEB-2021 12:00
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