|Salary:||£33,797 to £40,322 per annum (Grade 6)|
|Placed On:||12th February 2021|
|Closes:||28th February 2021|
Division of Infection and Immunity
School of Medicine
College of Biomedical and Life Sciences
Cancer immunotherapy has progressed significantly in recent years with improved understanding of how to boost the normally weak immune response to cancers. Nevertheless, there is considerable need for more improvements to ensure this form of treatment is more widely and effectively applied. Successful immunotherapy depends on immune cells, such as killer T lymphocytes, becoming activated and homing to the cancer. However, angiogenic blood vessels restrict entry of T lymphocytes to the cancer. Our studies of T lymphocyte trafficking in virus infection have generated a novel concept in protective immunity. Specifically, re-expression of L-selectin on early stage cytotoxic T cells is required for efficient recruitment from the bloodstream into infected organs in order to clear virus). Moreover, T cells which do not downregulate L-selectin on activation (L-selectin enhanced) are better able to clear virus due to increased recruitment into virus-infected tissues (http://dx.doi.org/10.1016/j.celrep.2015.12.090).
This Cancer Research UK funded post will determine whether enhanced L-selectin could be used for in cancer immunotherapy; novel findings will be tested in human T cells for rapid translation to the clinic. Candidates will have a PhD in a relevant biomedical research area, such as infection and immunity, cell biology or tumour immunology and a solid track record of research and academic achievement. Candidates with experience in leucocyte homing, vascular biology or imaging and are highly motivated to work in a competitive biomedical area are encouraged to apply. The candidate will join the Cancer Immunology Group whose members are working on complementary approaches to cancer immunotherapy such as vaccination, checkpoint blockade inhibition and manipulating the cancer microenvironment.
Informal enquires may be addressed to Dr Ann Ager, email: email@example.com.
This role is full time (35 hours a week), available from 1st March 2021 and is fixed term for 6 months.
Salary: £33,797 - £40,322 per annum (Grade 6) - please note a maximum salary of £36,914 per annum (spine point 33) applies to this post.
Closing date: Sunday, 28 February 2021
This post has previously been advertised to employees of Cardiff University only. We now invite external applications.
Cardiff University is committed to supporting and promoting equality and diversity and to creating an inclusive working environment. We believe this can be achieved through attracting, developing, and retaining a diverse range of staff from many different backgrounds. We therefore welcome applicants from all sections of the community regardless of sex, ethnicity, disability, sexual orientation, trans identity, relationship status, religion or belief, caring responsibilities, or age. In supporting our employees to achieve a balance between their work and their personal lives, we will also consider proposals for flexible working or job share arrangements.
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