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PhD Studentship: In the Department of Chemistry, University of Manchester with Dr Guillaume De Bo, Mechanochemistry with Mechanical Bonds

The University of Manchester

Qualification Type: PhD
Location: Manchester
Funding for: UK Students
Funding amount: £15,609 in 2021
Hours: Full Time
Placed On: 26th February 2021
Closes: 26th May 2021
 

This 4 year studentship funded by the Royal Society & The Department of Chemistry, will cover fees and stipend (£15,609 in 2021).
Open to UK students only.
Start date September 2021.

Project description 

Any force developed at the macroscopic scale can induce dramatic changes at the molecular scale, even breaking covalent bonds.[1] Indeed, mechanical force is a formidable source of energy that, with its ability to distort, bend and stretch chemical bonds, is unique in its ability to promote reaction pathways that are otherwise inaccessible to traditional methods of activation. A precise control of this force can be achieved when the chemical entity that is the subject of the mechanical force (a “mechanophore”) is embedded within a polymeric backbone.[2-5] Pulling both ends of a macromolecule apart creates highly directional strain with its highest intensity in the middle of the chain in a way reminiscent to a tug-of-war. The activation can be performed in solution, with the help of ultrasounds, or in the solid state, by simple stretching. 

Mechanical bonds have always fascinated chemists because of their intriguing nature and an undeniable aesthetic appeal. Since the first synthesis of a catenane in 1960, mechanical bonds have been used in a variety of contexts and their dynamic properties have been exploited to build molecular machines and new materials. The ability of their subcomponents to undergo large amplitude displacement, such as macrocycle shuttling in a rotaxane, make them ideal structures for mechanical coupling. We are currently investigating the rich array of mechanochemical behaviours displayed by catenanes and rotaxanes.[3-5] We have recently demonstrated that the activity of a mechanophore is altered when a rotaxane is used as a force actuator,[4] that rotaxanes under tension act as a lever that accelerate the dissociation of interlocked covalent bonds,[5] and that catenanes can act as mechanical protecting groups.[5] 

In this project you will use interlocked architectures (catenane/rotaxane) to promote unusual mechanochemical transformations and processes. You will investigate their activation both in solution, using ultrasounds, and in the solid-state by mechanical stretching, and explore their properties. This project could lead to the development of self-healing materials and to the creation of chemical systems able to perform complex synthetic tasks. 

You will be trained in synthetic organic, polymer, and supramolecular chemistry. 

Academic background of candidates:

Applicants are expected to hold, or about to obtain, a minimum upper second class undergraduate degree (or equivalent) in in Chemistry or Polymer Chemistry. An experience in synthetic organic chemistry, synthetic polymer chemistry or supramolecular chemistry is desirable.

Contact for further Information:

For more information on the group visit: http://www.deboresearchgroup.com

Follow us on Twitter: @GuillaumeDebo

For informal inquiries please contact Dr Guillaume De Bo at guillaume.debo@manchester.ac.uk (including a CV).

References

(1) De Bo, G. Macromolecules 2020, 53, 7615–7617.
(2) Nixon, R.; De Bo, G. Nat. Chem. 2020, 12, 826–831.
(3) Zhang, M.; De Bo, G. J. Am. Chem. Soc. 2018, 140, 12724.
(4) Zhang, M.; De Bo, G. J. Am. Chem. Soc. 2020, 142, 5029.
(5) Zhang, M.; De Bo, G. J. Am. Chem. Soc. 2020, 142, 5029.

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