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Postdoctoral Research Associate in Lymphoma Immunology and Immunotherapy

King's College London - Comprehensive Cancer Centre

Location: London
Salary: £38,304 to £45,026 including London Weighting Allowance
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 4th May 2021
Closes: 23rd May 2021
Job Ref: 021845
 

Job description

We are seeking to appoint a Postdoctoral Research Associate to join the translational Lymphoma Immunology group led by Dr Alan G. Ramsay. The group aims to identify effective combination immunotherapy and mechanisms of action within the tumour microenvironment/TME. In addition, we study and model the role of fibroblasts and endothelial cells within lymphoid tissue TMEs, as well as clinical trial-associated biomarker and bioassay studies to help advance the design of future therapies for patients.

Immunotherapy response rates have been disappointingly low in many B cell malignancies that develop within lymphoid tissues (chronic lymphocytic leukaemia, diffuse large B-cell lymphoma). This has highlighted the need to understand immunosuppressive mechanisms within these tumours (TMEs). This post represents a unique opportunity for an ambitious scientist to develop their scientific career and make significant contributions to an exciting and translationally focussed field with mentorship by Dr Ramsay and team.

The post will be based at Guy’s Cancer Centre, London Bridge allowing access to exceptional core laboratories including tissue culture (to model tumour, immune and stromal cell cultures), the Nikon Imaging Centre @ King’s (advanced confocal imaging) and the NIHR BRC Flow Cytometry and Genomics cores (high dimensional analysis facilities). Candidates are expected to have cell biology/tumour biology and immunology experience. This post is funded for 2 years in the first instance and interested applicants are encouraged to contact Dr Ramsay (alan.ramsay@kcl.ac.uk)

https://www.kcl.ac.uk/people/dr-alan-ramsay

https://loop.frontiersin.org/people/24610/overview

https://www.scopus.com/authid/detail.uri?authorId=24462154000

Recent publication from group:

Ioannou N, et al. Triggering interferon signaling in T cells with avadomide sensitizes CLL to anti-PD-L1/PD-1 immunotherapy. Blood. 2021 (Cover image and Commentary)

Apollonio B, et al. Understanding the Immune-Stroma Microenvironment in B Cell Malignancies for Effective Immunotherapy. Front Oncol. 2021.

This post will be offered as a fixed-term contract for 24 months in the first instance with expectation of extension.

This is a full-time post

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