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Research Associate (Dynamic Decisions: Integrating Dynamic Gene Expression with Mechanical Signals to Understand Retinogenesis and Ocular Disorders

The University of Manchester - Biology, Medicine & Health

Location: Manchester
Salary: £32,816 to £40,322 per annum, depending on relevant experience
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 11th June 2021
Closes: 23rd June 2021
Job Ref: BMH-016912
 

Job reference: BMH-016912

Location: Oxford Road, Manchester

Closing date (DD/MM/YYYY): 23/06/2021

Salary: £32,816 to £40,322 per annum, depending on relevant experience

Employment type: Fixed Term

Faculty/Organisation: Biology, Medicine & Health

School/ Directorate: Developmental Biology & Medicine

Hours per week: Full Time

Contract Duration: From 5 September 2021 until 4 September 2025

The Manning group seek a highly motivated scientist to join us studying the function and regulation of gene expression dynamics in retinal fate decisions, in particular how mechanical cues regulate oscillatory and pulsatile expression dynamics of HES1/5 and cell fate.

Dr Cerys Manning has recently established a research laboratory in the Faculty of Biology, Medicine and Health at The University of Manchester. The advertised position is funded by a five-year MRC Career Development Award awarded to Dr Manning. This is a great opportunity for a self-motivated, innovative, meticulous and organised candidate with excellent communication skills to work in a laboratory undertaking cutting edge research. 

The project aims to:

  • Determine functional importance of dynamic HES1/5 expression in retinal progenitor cells.
  • Characterise mechanical properties of retina and determine the impact of mechanical signals on retinal progenitor cell protein expression dynamics and cell fate decisions.
  • Determine the impact of mutations linked to microphthalmia and coloboma on cell fate.

We employ a sophisticated multidisciplinary approach to investigate the gene expression dynamics of retinal fate decisions, including ex-vivo or in vitro live-imaging studies of retinal progenitor cells, in-vitro ‘omics’, human iPSC derived retinal organoids, in-silico modelling methods, CRIPSR gene-editing, and aim to extend these efforts to include microfluidic tools. 

PhD-level experience in these areas is ideal, but applicants with similar interests and a strong track record in other cell and developmental biology fields are also actively encouraged. The position is available from 5st September 2021 and is tenable for at least 4.5 years. 

The School is strongly committed to promoting equality and diversity, including the Athena SWAN charter for gender equality in higher education. The School holds a Silver Award which recognises their good practice in relation to gender; including flexible working arrangements, family-friendly policies, and support to allow staff achieve a good work-life balance. We particularly welcome applications from women for this post. All appointment will be made on merit. For further information, please visit:

https://www.bmh.manchester.ac.uk/about/equality/

Blended working arrangements may be considered.

Please note that we are unable to respond to enquiries, accept CVs or applications from Recruitment Agencies.

Enquiries about the vacancy, shortlisting and interviews:

Name: Dr C Manning

Email: cerys.manning@manchester.ac.uk

General enquiries:

Email: hrservices@manchester.ac.uk

Technical support:

Email: https://jobseekersupport.jobtrain.co.uk/support/home

This vacancy will close for applications at midnight on the closing date.

Further particulars including job description and person specification are available on the University of Manchester website - click on the 'Apply' button above to find out more

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