|Salary:||Competitive with benefits, subject to skills and experience|
|Placed On:||22nd July 2021|
|Closes:||18th August 2021|
Fixed-term, 4 years
HBV is one of the smallest viruses to infect humans, but its biology and the mechanisms of disease remain incompletely understood, and it accounts for close to 300 million chronic cases worldwide, and a million deaths each year.
Our lab studies the interplay between host, virus and environment to better understand diverse outcomes of disease which range from spontaneous immune clearance or asymptomatic infection, through to inflammatory liver disease, cirrhosis, and hepatocellular carcinoma (HCC). A disproportionate burden of HBV disease falls upon low and middle-income countries, and we have close working partnerships with clinical research teams in South Africa and Uganda. We will also develop new partnerships with large HBV cohorts in London, providing an exciting opportunity to advance research in diverse populations represented locally.
As a group, we are setting out to address some fundamental questions about the molecular mechanisms of disease in HBV infection, with the aim of directly informing practical approaches in real-world cohorts that move us towards elimination. These include:
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.
The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
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