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Postdoctoral Training Fellow

The Francis Crick Institute - The Matthews Laboratory

Location: London
Salary: Competitive with benefits, subject to skills and experience
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 22nd July 2021
Closes: 18th August 2021
Job Ref: R331

Fixed-term, 4 years

Short summary

HBV is one of the smallest viruses to infect humans, but its biology and the mechanisms of disease remain incompletely understood, and it accounts for close to 300 million chronic cases worldwide, and a million deaths each year.

Our lab studies the interplay between host, virus and environment to better understand diverse outcomes of disease which range from spontaneous immune clearance or asymptomatic infection, through to inflammatory liver disease, cirrhosis, and hepatocellular carcinoma (HCC). A disproportionate burden of HBV disease falls upon low and middle-income countries, and we have close working partnerships with clinical research teams in South Africa and Uganda. We will also develop new partnerships with large HBV cohorts in London, providing an exciting opportunity to advance research in diverse populations represented locally. 

Project scope

As a group, we are setting out to address some fundamental questions about the molecular mechanisms of disease in HBV infection, with the aim of directly informing practical approaches in real-world cohorts that move us towards elimination. These include:

  • What is the burden of HBV infection and liver disease in diverse populations (UK, Uganda, South Africa, and others)? How can we best measure and quantify liver disease in different settings? How are these outcomes influenced by host, viral and environmental factors (ranging from host and viral genetics, to exposure to alcohol and aflatoxin)?
  • How can we refine approaches to predicting the emergence of liver disease using genomics, existing and novel laboratory biomarkers and imaging, in order to focus screening and therapy to best effect?
  • How can we better deploy existing antiviral therapy to prevent disease from emerging and to reduce the risk of transmission? As new therapies emerge onto the clinical stage, where are these best directed, and how can we use molecular medicine to measure outcomes?
  • How effective is vaccination in different populations, and to what extent is vaccine escape a current or future challenge?
  • How can these insights into disease, its treatment, and immunisation be applied at a population level to inform preventive strategies?

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy. 

  • If you are interested in applying for this role, please apply via our website.
  • The closing date for applications is 18 August 2021 at 23:59.
  • All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom. 
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