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Postdoctoral Research Associate in Chemistry - Grade 7

University of Liverpool - Chemistry

Location: Liverpool
Salary: £34,805 to £40,322 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 17th August 2021
Closes: 20th September 2021
Job Ref: 033355

The available post is focused on the design and synthesis of inhibitors of the protein cyclophilin D as potential therapies for acute pancreatitis (AP).  Your specific activities will include the design and synthesis of small molecule and semisynthetic inhibitors of cyclophilin D. We have found that pancreatic intracellular calcium overload is central to AP pathogenesis; induction of the mitochondrial permeability transition pore (MPTP) by calcium overload is critical in AP and inhibition of the MPTP by small molecule cyclophilin D inhibition is a highly effective treatment in experimental models. You should have a PhD in synthetic organic chemistry or in medicinal chemistry. You should have research experience in the synthesis, characterisation of organic compounds with a solid background knowledge of medicinal chemistry approaches, principles and applications. Expertise in molecular modelling would be desirable, but is not essential.

The post is available for 1.5 years initially with the possibility of an extension for a further 1.5 years.

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