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Dominant-negative Regulation of SQSTM1/p62 Droplet Autophagy and Neuro-proteotoxicity

University of Plymouth

Qualification Type: PhD
Location: Plymouth
Funding for: UK Students, EU Students
Funding amount: The studentship is supported for 3 years and includes full Home/EU tuition fees plus a stipend of £15,285 per annum. The studentship will only fully fund those applicants who are eligible for Home/EU fees with relevant qualifications
Hours: Full Time
Placed On: 25th August 2021
Closes: 19th October 2021

DoS Professor Shouqing Luo (shouqing.luo@plymouth.ac.uk, tel.: 01752 583205)

2nd Supervisor Dr Vikram Sharma (vikram.sharma@plymouth.ac.uk)

Applications are invited for a three-year PhD studentship. The studentship will start in January 2022.  Please submit your application for programme PhD Medical Studies.

Project Description

Autophagy is an evolutionarily conserved degradation process that is critical for clearance of intracellular aberrant components. It is implicated in various human physiological and pathological conditions, especially in neurodegenerative diseases, which are a great challenge to the modern society. It is important to understand the pathways and mechanisms to the development of the devastating diseases.

Selective autophagy degrades autophagy substrates in a selective manner through protein-protein interaction mechanisms. The PhD studentship aims to investigate protein droplet-based autophagy and its potential implication in neuro-proteotoxicity. Experiments will be performed using molecular and cell biological tools with cell lines, patient-derived IPSC-induced neurons, and other physiologically relevant models. Training will be provided for the development of both knowledge and technical skills to enable the trainee to conduct high-quality and independent scientific research in the fields of autophagy and programmed cell death. For more information, please see our recent publications: Button RW, et al, J Biol Chem 292:13599, 2017; Yang Y, et al, Nat Commun 10:3759, 2019; Roberts et al, Hum Mol Genet 29:216, 2020; Valionyte et al, J Mol Biol 432:2673, 2020; Li et al, Nature 575:203, 2019.

Eligibility

Applicants should have (at least) a first or upper second class honours degree in an appropriate subject and preferably a relevant MSc or MRes qualification.

The studentship is supported for 3 years and includes full Home/EU tuition fees plus a stipend of £15,285 per annum.  The studentship will only fully fund those applicants who are eligible for Home/EU fees with relevant qualifications.  Applicants normally required to cover overseas fees will have to cover the difference between the Home/EU and the overseas tuition fee rates (approximately £12,763 per annum).

If you wish to discuss this project further informally, please contact Prof Shouqing Luo at shouqing.luo@plymouth.ac.uk. However, applications must be made in accordance with the details shown below.

General information about applying for a research degree at the University of Plymouth and to apply for this position please visit: https://www.plymouth.ac.uk/student-life/your-studies/research-degrees

For more information on the admissions process contact doctoralcollege@plymouth.ac.uk.

The closing date for applications is noon on Tuesday 19 October 2021. Shortlisted candidates will be invited for interview around 2 weeks after the closing date. We regret that we may not be able to respond to all applications. Applicants who have not received an offer of a place by the end of November should consider their application has been unsuccessful on this occasion.

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