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Staff Scientist in CRISPR Genetic Manipulation

Wellcome Sanger Institute - Vento-Tormo Lab

We are looking to appoint a highly motivated staff scientist to join Roser Vento-Tormo’s group at the Wellcome Sanger Institute.

You will be integrated in the Vento-Tormo lab, a highly collaborative, international work environment with well-experienced colleagues in single-cell and spatial data production, use of in vitro models, analysis and methods development ( You will be responsible for the development of novel genetic engineering tools to be applied on multiple in vitro models available in the lab, working closely with the Bassett team ( You will generate new synthetic constructs that regulate gene expression or alter genomic sequence during in vitro differentiation as well as develop novel genome editing tools to record lineage tracing. You will have the opportunity to be embedded in and supported by a large community of experimental and computational scientists with access to the world-leading computational and experimental facilities at the institute.

Vento-Tormo’s lab research interest is to understand the influence of cellular microenvironments on individual cellular identities and responses, in the context of development and immunity. The team employs single-cell and spatial transcriptomics methods to deconstruct the cell signals in human organs and tissues, and utilise this information to inform the reconstruction of novel in vitro models. The lab is based at the Sanger Wellcome Institute (WSI) a dynamic, multi-disciplinary, innovative institute in Cambridge (UK) and works closely with other teams single-data within the cellular genetics program and the European Bioinformatics Institute (EBI) to advance in the genomics field.

Relevant publications of the team:

-  Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro. Garcia-Alonso L,…, Vento-Tormo RBioRxiv doi: (Accepted in Nature Genetics)

-  A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre. Mole M, …, Vento-Tormo R*, Zernicka-Goetz M*. Nature Communications. 2021 Jun 17;12(1):3679. (* co-corresponding)

-  CellPhoneDB: Inferring cell-cell communication from combined expression of multi-subunit receptor-ligand complexes. Efremova M, Vento-Tormo M, Teichmann SA, Vento-Tormo R. Nature Protoc. 2020 Apr;15(4):1484-1506.

Essential Skills

 Technical Skills:

  • PhD in relevant wet-lab subject (e.g. Molecular Biology, Developmental Biology) 
  • Post-doctoral experience including proven track record (publications and meetings) in field of expertise.
  • Experience using CRISPR editing tools 
  • Extensive experience of molecular biology (e.g. vector design and construction) 
  • Comprehensive, up to date and in depth understanding of CRISPR-based genetic screening, stem cell culture and differentiation 
  • Practical experience in mammalian tissue culture. Ideally in mammalian ES or iPS 

 Competencies and Behaviours:

  • Ability to test, implement and troubleshoot new approaches and techniques 
  • Excellent communication skills 
  • Proven ability to work effectively within a team 
  • Self-motivated, able to be independent and organised 
  • Good attention to detail and record keeping for sample and experimental tracking 
  • An ability to lead and inspire others to achieve scientific projects 

Other information

Application Process:

Please apply with your CV and a Cover letter outlining your suitability for the role addressing the criteria set out above and in the job description.

Location: Cambridge, Hinxton
Salary: £37,865 to £45,359 Grade 2
Hours: Full Time
Contract Type: Permanent
Placed On: 23rd September 2021
Closes: 31st October 2021
Job Ref: 84460
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