|Salary:||£41,593 to £45,234 per annum|
|Placed On:||1st October 2021|
|Closes:||2nd November 2021|
Department: Institute of Clinical Sciences
Salary: Between £41,593 – 45,234 per annum
Location: Hammersmith Campus
Contract: Full time & Fixed Term for 3 years
Two positions have become available in the laboratory of Professor Speck at Imperial College London (http://www.specklab.com/) to investigate mechanisms of human DNA replication and their misregulation in cancer employing biochemical & structural or genomic approaches.
The two research associates will collaborate extensively as part of the overall project and work together with 3 PhD students investigating related, but not overlapping questions.
The current group consists of 11 researchers, including 6 postdocs, 4 students and one technician. The successful candidates will enjoy intensive interactions with group members specialised in cryo-EM, biochemistry, high resolution genomic (ChIP-Exo) and proteomic (ChIP-MS) approaches generating a collaborative and highly productive atmosphere. We are excellent equipped for biochemistry (2 AKTA’s, 4 temperature-controlled shakers, 2 freezer mills, Constant System French Press, Biacore T100), structural EM work (cryo-EM facility with Talos 200kV FEG cryo-EM Falcon 3, Vitrobot IV, Leica GP2, GPU- and data storage-cluster and direct access to a Titan Krios with K3 detector as founding member of the LonCEN consortium) and genomics/proteomics (direct access to excellent local sequencing, genomics and proteomics facilities and bioinformatics team).
By joining the group, the candidates will not only participate in high profile research projects but will also be directly mentored by Professor Speck in grant writing, networking and publishing. Indeed, the scientific framework and the support by Prof. Speck means that the candidates are well placed for a successful transition into independence.
Duties and responsibilities:
BIOCHEMISTRY & STRUCTURAL BIOLOGY (2 Positions)
Biochemistry and structural biology have the potential to reveal highly complex molecular mechanisms. In particular in vitro reconstitution and cryo-electron microscopy are ideally suited to investigate the structure, function and regulation of large protein assemblies. The successful applicants will work on a cutting-edge project focussed on DNA replication. We aim to discover how DNA replication origins are specified (position 1) and how DNA replication is regulated (position 2) to support genome stability and achieve faithful DNA replication. Expertise in protein purification, biochemical assays and/or cryo-EM analysis of protein complexes is essential.
Essential and desired requirements
Position 1 (stronger focus on biochemistry):
Position 2 (stronger focus cryo-EM)
The 2 positions are Full Time & Fixed Term posts being offered for 36 months based at the Hammersmith Campus, London.
Should you require any further details on the role please contact: Christian Speck – email@example.com.
Type / Role: