|Funding for:||UK Students, EU Students|
|Funding amount:||BBSRC SWBio DTP funded CASE studentship available for September 2022 entry. The studentship will provide funding of fees and a stipend which is currently £15,609 per annum for 2022-23, on a full time basis.|
|Placed On:||22nd October 2021|
|Closes:||6th December 2021|
Evidence is accumulating that a father’s condition can be transferred non-genetically to the next generation and affect offspring development, performance and health.
To date, the mechanisms underlying such paternal condition-transfer effects remain poorly understood and their evolutionary consequences are largely unexplored. In this project you will use a bird model system (Japanese quail, Coturnix japonica), in which paternal condition-transfer effects on offspring reproductive performance have previously been demonstrated, to identify the origin, function and evolutionary consequences of non-genetic paternal effects using a highly multidisciplinary and integrative approach.
Using in vivo experiments combined with state-of-the-art molecular and physiological techniques you will test how favourable or harsh early life conditions experienced by males affect their sperm and seminal fluid composition, and how different components of the male’s ejaculate mediate inter-generational effects on the daughters’ reproductive performance and health. Experimental in vivo and molecular work will be complemented by evolutionary modelling to quantify the role of paternal condition-transfer effects in altering the response to selection, as well as the potential of experimental interventions to modify evolutionary trajectories of reproductive traits under selection through paternal effects.
The project will provide fundamental novel insights into the mechanisms underlying paternal condition-transfer effects across generations and the potential of early life interventions to alter evolutionary trajectories, both directly relevant to the management of animal health and performance as well as our understanding of the reproductive lives of birds.
During the project you will obtain interdisciplinary training in a variety of state-of-the-art approaches and techniques that are highly sought-after by employers in and outside of academia, including experimental in vivo skills, molecular techniques, bioinformatics, and mathematical modelling. You will be based in a thriving, friendly and inclusive department and benefit from the complementary expertise of a highly multidisciplinary supervisory team.
To be eligible for a fully-funded studentship, you must meet both the academic and residence criteria.
Please refer to the regulations or Annex 1 of the Research Council Training Grant Guide to confirm that you meet the residence criteria for a fully-funded studentship. Any further queries in relation to residency must be directed to the institution that you are applying to.
* An enhanced stipend is available for students with a recognised veterinary degree qualification (£24,090 per annum for 2021-2022). There may also be enhanced stipends associated with projects that have a CASE partner (CASE projects are highlighted as *CASE in the project lists).
Applicants should have obtained, or be about to obtain, a 1st or 2:1 UK Honours degree, or equivalent qualifications gained outside the UK, in an appropriate area of science or technology. Applicants with a Lower Second Class degree will be considered if they also have Masters degree or significant relevant non-academic experience.
In addition, a minimum of a grade B in A-level Maths or equivalent qualification or experience is required.
* eg maths, statistics, bioinformatics.
Applicants must highlight their Maths background within their application and upload any supporting evidence.
This project is one of a number that are in competition for funding from the South West Biosciences Doctoral Training Partnership (SWBio DTP).
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