Back to search results

Developing "discovery toolkits" for thiamine diphosphate-dependent enzymes as herbicide targets

University of Exeter - College of Life and Environmental Sciences

Qualification Type: PhD
Location: Exeter
Funding for: UK Students, EU Students
Funding amount: BBSRC SWBio DTP funded CASE studentship available for September 2022 entry. The studentship will provide funding of fees and a stipend which is currently £15,609 per annum for 2022-23, on a full time basis.
Hours: Full Time
Placed On: 25th October 2021
Closes: 6th December 2021
Reference: 4288

In this project, you will make the first steps in a discovery campaign aimed at identifying novel herbicides. The project will teach you skills in protein preparation, enzymology, protein structure determination, microbiology, molecular biology, and molecular modelling. 

You will learn protein science and enzymology methods broadly applicable to drug discovery. For protein structure determination, the project will provide opportunities to work with experts in X-ray crystallography and single particle cryo-electron microscopy, with the possibility of using micro-electron diffraction if suitable samples are obtained. You will also have the opportunity to carry out small scale compound screens against suitable targets.     

The aim of the project will be to develop a “discovery toolkit” for one or more enzymes found in model weeds. These enzymes are expected to be essential for weed growth and are not found in humans. In the project, you will prepare these enzymes and determine their kinetic properties to identify likely ideal binding sites for inhibitors. You will determine the structures of the proteins in complex with their substrates or products. Finally, you will build assays that could be used for testing potential inhibitors of the enzymes in vitro or in vivo, and test these with small inhibitor libraries. This collection of data and methods will allow the project partner to screen larger compound libraries in the future.     

The project will offer a challenging and interdisciplinary PhD in cutting edge research areas. All these methods are well established in the supervisor’s groups.There will be opportunities to also learn associated methods that the laboratories specialise in as the project develops. The project will also offer considerable opportunities to interact with the partner Syngenta, and other collaborators in our wider network. Syngenta will host the industrial placement at its Jealott’s Hill site, which is Syngenta’s largest R&D site globally and includes multiple different disciplines from high-throughput screening to lead-optimisation, formulation and development. The placement will most likely be in the third year of the PhD.     

This project will be based in the recently established Living Systems Institute in Exeter, which houses a diverse group of leading interdisciplinary researchers, and in the Henry Wellcome Building for Biocatalysis. You will join a vibrant group of young researchers with interests across a range of diseases.   

Eligibility 

To be eligible for a fully-funded studentship, you must meet both the academic and residence criteria. 

A fully-funded four year SWBio DTP studentship will cover 

  • a stipend* at the standard Research Council UK rate; currently £15,609 per annum for 2022-23
    •    research and training costs 
    •    tuition fees (at the standard Research Councils UK rate) 
    •    additional funds to support fieldwork, conferences and a 3-month internship 

Please refer to the regulations or Annex 1 of the Research Council Training Grant Guide to confirm that you meet the residence criteria for a fully-funded studentship.  Any further queries in relation to residency must be directed to the institution that you are applying to. 

* An enhanced stipend is available for students with a recognised veterinary degree qualification (£24,090 per annum for 2021-2022). There may also be enhanced stipends associated with projects that have a CASE partner (highlighted as *CASE in the project lists). 

The award: 

This project is one of a number that are in competition for funding from the South West Biosciences Doctoral Training Partnership (SWBio DTP). 

We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Subject Area(s):

Location(s):

PhD tools
 

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Ok Ok

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Manage your job alerts Manage your job alerts

Account Verification Missing

In order to create multiple job alerts, you must first verify your email address to complete your account creation

Request verification email Request verification email

jobs.ac.uk Account Required

In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account

Create Account Create Account

Alert Creation Failed

Unfortunately, your account is currently blocked. Please login to unblock your account.

Email Address Blocked

We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.

Max Alerts Reached

A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert

Manage your job alerts Manage your job alerts

Creation Failed

Unfortunately, your alert was not created at this time. Please try again.

Ok Ok

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

 
 
 
More PhDs from University of Exeter

Show all PhDs for this organisation …

More PhDs like this
Join in and follow us

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge