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PhD scholarship

University of Hull

Location: Kingston upon Hull
Salary: Fee waiver for 21/22 is £4500 (Home fee) and the maintenance grant is £15609
Hours: Full Time, Part Time
Contract Type: Fixed-Term/Contract
Placed On: 10th November 2021
Closes: 7th January 2022

Exercise for improving chemoradiotherapy efficacy in patients diagnosed with oesophagogastric and colorectal cancers

About this project

Emerging evidence from preclinical and clinical studies shows that exercise during chemo-radiotherapy cycles has the potential to improve cancer treatment efficacy. Purported mechanisms include enhanced targeting of chemo-radiotherapy treatments via exercise-induced modulation of the tumour vasculature and favourable changes to the tumour microenvironment. This PhD project will establish how exercise can be embedded within the cancer care pathways for oesophagogastric and colorectal cancer patients undergoing neoadjuvant chemo-radiotherapy and radical chemo-radiotherapy as a definitive non-surgical option. The effects of exercise on treatment efficacy will then be assessed by comparison of radiological and biological tumour response rates between patients randomised to exercise in addition to standard care versus standard care alone.

You will be joining a large multidisciplinary team with a strong track record of leading research trials (including randomised controlled exercise trials) in people living with and beyond cancer. Working in a supportive, collegiate environment, you will have outstanding career development opportunities through the support provided by the Doctoral College and access to research seminars and workshops in the Department of Sport, Health & Exercise Science, the Hull York Medical School and the Hull University Teaching Hospitals NHS Trust. You will also engage in regular meetings with other PhD students and supervisors working on related projects as part of the larger research cluster.

For informal inquiries, please contact Professor John M Saxton: john.saxton@hull.ac.uk

About the research cluster

This PhD cluster aims to develop an exercise model that can be embedded within the oesophagogastric and colorectal cancer care pathways and provide evidence that it can influence and potentially improve the efficacy of chemo-radiotherapy treatments. In addition, the cluster aims to provide new mechanistic insights into the role of exercise for ameliorating the adverse cardiotoxic and myotoxic side-effects of chemo-radiotherapy and undertake qualitative investigations aimed at understanding the barriers and levers to embedding exercise within cancer care pathways and informing the development of good practice implementation guidelines.

Funding

The successful applicant will receive a fee waiver and a maintenance grant / stipend for three years (full-time) or five years (part-time), which covers the research period of the PhD. The fee waiver for 21/22 is £4500 (Home fee) and the maintenance grant is £15609. This rises each year in line with the UKRI’s recommended stipend allowance.

Submission of thesis

Submission of your final thesis is expected within three years and three months from the start of your PhD scholarship for full time and within five years and six months if studying part-time.

If you need to move into a fourth year (full time) or sixth year (part-time) to complete your thesis, please note that you will not receive a tuition fee waiver or maintenance grant during this period.

Eligibility, entry requirements and how to apply To find out more about the eligibility criteria, entry requirements and how to apply, please visit the University of Hull PhD scholarships webpage.

International applicants

This opportunity comes with a home fee waiver only.

Closing date for applications

17.00 on Friday 7th January 2022.

 

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