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Research Assistant/Associate in Implantable Drug Delivery Devices for Brain Tumours (Fixed Term)

University of Cambridge - Department of Engineering

Location: Cambridge
Salary: £27,116 to £40,927
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 18th November 2021
Closes: 7th December 2021
Job Ref: NM29043

A position exists, for a Research Assistant/Associate to design, fabricate and validate implantable devices that delivery chemotherapy to brain tumours, as part of  a broader  EPSRC IRC project to explore the  use of new technologies to combat hard-to-treat cancers.

Background to the Project

Chemotherapy drugs have poor penetration through the blood brain barrier (BBB) leading to sub-therapeutic concentrations in brain tumours. Therapeutic strategies that control drug release spatially and temporally represent a significant step forward in terms of reducing side-effects and improving treatment efficacy and will thus have significant clinical impact. Electrophoretic drug delivery devices, which use electric fields to enhance drug transport, represent one such strategy. The aim of this project is to make implantable electrophoretic drug delivery devices and validate them in animal models of brain cancer, generating the necessary preclinical data to support translation.

Applicants must have (or be close to obtaining) a PhD or equivalent in Engineering or Physical Sciences, and experience with the fabrication and validation in animal models of implantable devices, including at least one of the following:

- Convection enhanced delivery catheters

- Microdialysis devices

- Neural implants

- Implantable sensors

Applicants must have demonstrated ability to function within a large team, coordinate with multiple partners, and communicate across disciplines. They must have experience of collaborating with experimental oncology/neuroscience groups, experience with implantable device validation in rodents, and a strong publication record in relevant journals.

Key responsibilities and duties include device development and applicants should be able to evaluate

 different fabrication strategies and select the most appropriate one, generate prototypes that include  

 electrical and fluidic connections and provide devices to IRC collaborators for studies of mechanical  properties and sterilization etc.

Applicants should also be able to work with IRC collaborators to evaluate device performance in in vitro models and should be able to work with an in vivo validation team to evaluate device performance.

Planning and organization is also important with applicants being expected to plan the use of research resources, laboratories and workshops. Applicants are also expected to manage their own research activity, in collaboration with others.

Fixed-term: The funds for this post are available for 12 months in the first instance.

To apply online for this vacancy and to view further information about the role, please visit :

http://www.jobs.cam.ac.uk/job/32412.

Please ensure that you upload your Curriculum Vitae (CV) and a covering letter in the Upload section of the online application. If you upload any additional documents which have not been  requested, we will  not be able to consider these as part of your application. Please submit your application by midnight on the closing date.

If you have any questions about this vacancy please contact George Malliaras (gm603@cam.ac.uk) for queries of a technical nature related to the role. For queries relating to the application process, please contact Kirsty Shepherd (kjs64@cam.ac.uk).

Please quote reference NM29043 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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