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Research Associate in Structure Based Drug Design

Newcastle University

Location: Newcastle upon Tyne
Salary: £31,406 to £40,927 per annum.
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 23rd November 2021
Closes: 13th December 2021
Job Ref: 11462

We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the Northeast of England. Attracting and retaining high-calibre people is fundamental to our continued success.

The Role
You will be responsible for driving an academic-industrial collaboration, with Bicycle Therapeutics on the structural and biophysical characterisation of bicyclic peptides in complex with their therapeutic protein targets.

Within the lab of Prof. Wyatt Yue, your role is to conduct an industry-funded project, aimed towards a molecular understanding of how bicyclic peptides can engage target proteins via different binding mechanisms, through generating a series of protein-based biophysical and 3D structural data to drive ligand design.

Find out more about our Research Institutes here: https://www.ncl.ac.uk/medical-sciences/research/institutes/

Find out more about the Faculty of Medical Sciences here: https://www.ncl.ac.uk/medical-sciences/

This post is full-time, fixed-term for a period of 2 years.

For informal enquiries contact: Wyatt Yue, Professor of Structural Biology at wyatt.yue@newcastle.ac.uk.

Key Accountabilities
Within the lab of Prof. Wyatt Yue, your role is to conduct an industry-funded project, aimed towards a molecular understanding of how bicyclic peptides can engage target proteins via different binding mechanisms, through generating a series of protein-based biophysical and 3D structural data to drive ligand design.

  • Although working under the general guidance of an academic or Principal Investigator, the postholder will contribute ideas, including enhancements to the technical or methodological aspects of their studies, thus providing substantial 'added value'.
  • Develop and carry out the specified project using appropriate techniques and equipment as outlined in the personal requirements.
  • Determine appropriate methodologies for research, with advice and support where required.
  • Contribute to grant applications submitted by others and in time develop own research objectives and proposals for funding.
  • Begin to write, with appropriate support, proposals for individual research funding or, where funders do not permit this, contribute to the writing of collective bids.
  • Assess research findings for the need/scope for further investigations.
  • Contribute to the writing up of their research for publication and dissemination, either through seminar and conference presentations or through publications.
  • Present research findings, either at conferences or through publications in reputable outlets appropriate to the discipline.
  • May be involved in the supervision, with guidance, of final year undergraduate research projects and in providing support to postgraduate research students or Research Assistants.
  • Will need to work with the support staff and, on occasions, with undergraduate and postgraduate students, and interact intellectually with other academic members of the Institute.
  • May contribute to events celebrating the public engagement of science/social sciences/humanities.
  • Develop an awareness of University structures, policies and procedures and relevant issues in the higher education, research, social and political environment.
  • Recombinant protein production in baculovirus-mediated insect and mammalian expression systems.
  • Biophysical studies involving enzyme kinetics, ligand binding, and protein-protein interaction (ITC, SPR, BLI).
  • Protein-ligand co-structures using x-ray crystallography and complementary approaches.

Qualifications

  • A PhD and experience in the research area of structural biology or protein biochemistry.
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